A
Anna Spada
Researcher at University of Milan
Publications - 326
Citations - 13577
Anna Spada is an academic researcher from University of Milan. The author has contributed to research in topics: Pituitary tumors & Acromegaly. The author has an hindex of 60, co-authored 322 publications receiving 12683 citations. Previous affiliations of Anna Spada include Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
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Journal ArticleDOI
Presence of an adenylate cyclase dually regulated by somatostatin and human pancreatic growth hormone (GH)-releasing factor in GH-secreting cells.
TL;DR: The results suggest the presence of a dually regulated AC in GH-secreting cells; an involvement of cAMP in the intracellular mechanisms transducing the signals of SRIF and hpGRF-44 in somatotrophs.
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Autosomal Dominant Pseudohypoparathyroidism Type Ib: A Novel Inherited Deletion Ablating STX16 Causes Loss of Imprinting at the A/B DMR
Francesca Elli,Luisa de Sanctis,Erika Peverelli,Paolo Bordogna,Barbara Pivetta,Gianmaria Miolo,Paolo Beck-Peccoz,Anna Spada,Giovanna Mantovani +8 more
TL;DR: This work highlights the importance of performing accurate investigations in PHP-Ib patients with methylation defects to allow precise genetic counseling because, in case of deletions, the segregation ratio is about 50% and the disease phenotype is transmitted in an autosomal dominant fashion via the mother.
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In vitro studies on prolactin release and adenylate cyclase activity in human prolactin-secreting pituitary adenomas. Different sensitivity of macro- and microadenomas to dopamine and vasoactive intestinal polypeptide.
Anna Spada,Simonetta Nicosia,L. Cortelazzi,Giulio Pezzo,Monique Bassetti,Alessandro Sartorio,G. Giannattasio +6 more
TL;DR: A number of human PRL-secreting pituitary adenomas were tested for their in vitro responsiveness to dopamine (DA) and vasoactive intestinal polypeptide (VIP) and PRL release from tumor fragments and adenylate cyclase activity in membrane fractions were evaluated.
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Some aspects of hypothalamic-pituitary function in patients with anorexia nervosa.
P. Travaglini,Paolo Beck-Peccoz,Carlo Ferrari,Bruno Ambrosi,A. Paracchi,A. Severgnini,Anna Spada,Giovanni Faglia +7 more
TL;DR: The present data suggest that the primary failure in gonadotrophin secretion in anorexia nervosa occurs at hypothalamic level; moreover the data on TSH and PRL secretion also point to the existence of a hypothalamic disorder in this disease.
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Mutational analysis of GNAS1 in patients with pseudohypoparathyroidism : Identification of two novel mutations
Giovanna Mantovani,Roberto Romoli,Giovanna Weber,V. Brunelli,E. De Menis,S. Beccio,Paolo Beck-Peccoz,Anna Spada +7 more
TL;DR: The first mutational analysis of Italian patients with PHP Ia and PPHP is reported, and two novel deletions in GNAS1 are described, suggesting that these forms of AHO are genetically distinct fromPHP.