Anna Spada

TL;DR: Treatment of pituitary gigantism with pegvisomant was effective and well tolerated in a young giant unresponsive to combined cabergoline and octreotide treatment.

TL;DR: The phenotype associated with this structural rearrangement, which substantially reduces the synthesis of Wolframin, confirms a tissue-specific pattern of expression of WFS1, suggests the presence of a different protein dosage sensitivity in different tissues and could be causative of DI and OA in this patient.

TL;DR: Macroadenomas and age are risk factors for SHD in CNFPIs, which occur at diagnosis in a quarter of patients, and during follow-up, macroadanomas tend to grow more often, but microadenomas display higher growth trend as follow- up increases.

TL;DR: In this paper, the authors investigated the possible association of gene polymorphisms and susceptibility to diseases and/or resistance to drugs and found that polymorphic variants in SST2 and SST5 genes seem to have a minor, if any, role in determining the different responsiveness to somatostatin analogs in patients with acromegaly.

TL;DR: The present study clearly indicates that although the large majority of nonfunctioning tumors are positive for gonadotropins their secretory capacity is very low in both basal and stimulated conditions.