A
Anna Spada
Researcher at University of Milan
Publications - 326
Citations - 13577
Anna Spada is an academic researcher from University of Milan. The author has contributed to research in topics: Pituitary tumors & Acromegaly. The author has an hindex of 60, co-authored 322 publications receiving 12683 citations. Previous affiliations of Anna Spada include Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
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Journal ArticleDOI
The Third Intracellular Loop of the Human Somatostatin Receptor 5 Is Crucial for Arrestin Binding and Receptor Internalization after Somatostatin Stimulation
Erika Peverelli,Giovanna Mantovani,Davide Calebiro,Andrea Doni,Sara Bondioni,Andrea Lania,Paolo Beck-Peccoz,Anna Spada +7 more
TL;DR: The results indicate the SST5 third intracellular loop as an important mediator of beta-arrestin/receptor interaction and receptorinternalization, whereas they suggest that residues 328-347 within the C terminus may play an inhibitory role in receptor internalization.
Journal ArticleDOI
The trans-sphenoidal resection of pituitary adenomas in elderly patients and surgical risk
Marco Locatelli,Giulio Bertani,Giorgio Carrabba,Paolo Rampini,Mario Zavanone,Manuela Caroli,Elisa Sala,Emanuele Ferrante,Sergio M. Gaini,Anna Spada,Giovanna Mantovani,Andrea Lania +11 more
TL;DR: In specialized centres the surgical treatment of pituitary adenomas via the transsphenoidal route can be a safe and effective procedure even in elderly patients.
Journal ArticleDOI
Patients with macroprolactinaemia: clinical and radiological features
F. Donadio,Anna Maria Barbieri,R. Angioni,Giovanna Mantovani,Paolo Beck-Peccoz,Anna Spada,Andrea Lania +6 more
TL;DR: The aim of this study was to investigate the clinical and neuroradiological characteristics of patients with and without macroprolactinaemia and to evaluate the impact of macro Prolactin determination on the diagnostic work‐up of hyperprolACTinaemic patients.
Journal ArticleDOI
Microvasculature of human micro- and macroprolactinomas: a morphological study
TL;DR: The different blood supply to the small and large tumors could result in a different availability of regulatory factors for the two types of tumors, and the different frequency of capillaries in micro- and macroprolactinomas could have some important consequences as to the regulation of the hormonal secretion.
Journal ArticleDOI
Growth hormone receptor variants and response to pegvisomant in monotherapy or in combination with somatostatin analogs in acromegalic patients: a multicenter study.
Marcello Filopanti,Luca Olgiati,Giovanna Mantovani,Sabrina Corbetta,Maura Arosio,Valentina Gasco,L. De Marinis,Carlo Martini,F. Bogazzi,Salvatore Cannavò,A. Colao,Diego Ferone,Giorgio Arnaldi,Francesca Pigliaru,Alessandro Peri,Gabriella Angeletti,Marie Lise Jaffrain-Rea,Andrea Lania,Anna Spada +18 more
TL;DR: This study did not confirm a better response of d3GHR to PEG-V treatment in acromegaly and other studies are needed to determine whether deviation from Hardy-Weinberg equilibrium may indicate an association of d2GHR genotype with poor response to usual treatments.