Annamaria Rapisarda

TL;DR: It is described that oxygen availability is a determinant parameter in the setting of chemotactic responsiveness to stromal-derived factor 1 (CXCL12), and the Hyp–Hyp-inducible factor 1 α–CXCR4 pathway may regulate trafficking in and out of hypoxic tissue microenvironments.

TL;DR: The luciferase-based high-throughput screen is a feasible tool for the identification of small molecule inhibitors of HIF-1 transcriptional activation and the results suggest that altered Topo-I function may be associated with repression of Hif-1-dependent induction of gene expression.

TL;DR: The results revealed the functional plasticity of monocytes during human sepsis, wherein they transited from a pro-inflammatory to an immunosuppressive phenotype, while enhancing protective functions like phagocytosis, anti-microbial activity, and tissue remodeling.

TL;DR: It is demonstrated that TPT does not affect Hif-1α protein half-life or mRNA accumulation but inhibits its translation, and the existence of a novel pathway connecting Top 1-dependent signaling events and the regulation of HIF-1 α protein expression and function is demonstrated.

TL;DR: The present research attacked the mechanism of action of HIF‐1 inhibitors by targeting the ‘spatially reprograming’ pathway, which results in down-regulation of Hif‐1α transcriptional activity.