A
Anne Kleijn
Researcher at Erasmus University Rotterdam
Publications - 17
Citations - 584
Anne Kleijn is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Oncolytic virus & Glioma. The author has an hindex of 10, co-authored 14 publications receiving 450 citations. Previous affiliations of Anne Kleijn include University of Southern California & Children's Hospital Los Angeles.
Papers
More filters
Journal ArticleDOI
Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells
Jeroen de Vrij,S L Niek Maas,Kitty M. C. Kwappenberg,Rosalie Schnoor,Anne Kleijn,Lennard J. M. Dekker,Theo M. Luider,Lot de Witte,Manja Litjens,Miriam E. van Strien,Elly M. Hol,Jérôme Kroonen,Pierre A. Robe,Martine L.M. Lamfers,Marco W. Schilham,Marike L. D. Broekman +15 more
TL;DR: GBM‐derived EVs can modify cells of the monocytic lineage, which acquire characteristics that resemble the tumor‐supportive phenotypes observed in patients.
Journal ArticleDOI
Delta-24-RGD Oncolytic Adenovirus Elicits Anti-Glioma Immunity in an Immunocompetent Mouse Model
Hong Jiang,Karen Clise-Dwyer,Kathryn Ruisaard,Xuejun Fan,Weihua Tian,Joy Gumin,Martine L.M. Lamfers,Anne Kleijn,Frederick F. Lang,W. K. A. Yung,Luis M Vence,Candelaria Gomez-Manzano,Juan Fueyo +12 more
TL;DR: It is demonstrated that Delta-24-RGD induces anti-glioma immunity and offers the first evidence that viral infection directly enhances presentation of tumor-associated antigens to immune cells.
Journal ArticleDOI
The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity.
Anne Kleijn,Jenneke Kloezeman,Elike Treffers-Westerlaken,Giulia Fulci,Sieger Leenstra,Clemens M F Dirven,Reno Debets,Martine L.M. Lamfers +7 more
TL;DR: Delta24-RGD treatment led to long-term survival in 50% of mice and this effect was completely lost upon administration of the immunosuppressive agent dexamethasone, providing evidence that the immune system plays a vital role in the therapeutic efficacy of oncolytic adenovirus therapy of glioma.
Journal ArticleDOI
Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules
Rutger K. Balvers,Anne Kleijn,Jenneke Kloezeman,Pim J. French,Andreas Kremer,Martin J. van den Bent,Clemens M F Dirven,Sieger Leenstra,Martine L.M. Lamfers +8 more
TL;DR: SF cultures are derived from a subset of parental tumors with a shared molecular background including enrichment for extracellular matrix-associated gene modules, which provides leads to develop enhanced culture protocols for glioma samples not propagatable under current SF conditions.
Journal ArticleDOI
Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment
Wouter B.L. van den Bossche,Anne Kleijn,Charlotte E. Teunissen,Jane S. A. Voerman,Cristina Teodosio,David P. Noske,Jacques J.M. van Dongen,Jacques J.M. van Dongen,Clemens M F Dirven,Martine L.M. Lamfers +9 more
TL;DR: It is demonstrated that local Delta24-RGD therapy may provide a therapeutic tool to promote a prolonged shift in the protumoral M2 macrophages toward M1 in human GBM, inducing a pro-inflammatory and potentially tumor-detrimental microenvironment.