D
David P. Noske
Researcher at VU University Medical Center
Publications - 65
Citations - 3681
David P. Noske is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 26, co-authored 52 publications receiving 2895 citations. Previous affiliations of David P. Noske include VU University Amsterdam.
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Journal ArticleDOI
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Myron G. Best,Nik Sol,Irsan E. Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger +23 more
TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
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Blood platelets contain tumor-derived RNA biomarkers
R. Jonas A. Nilsson,R. Jonas A. Nilsson,Leonora Balaj,Leonora Balaj,Esther Hulleman,Sjoerd van Rijn,D. Michiel Pegtel,Maudy Walraven,Anders Widmark,Winald R. Gerritsen,Henk M.W. Verheul,W. Peter Vandertop,David P. Noske,Johan Skog,Thomas Wurdinger,Thomas Wurdinger +15 more
TL;DR: It is demonstrated that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and it is shown that platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively.
Journal ArticleDOI
In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma
Shahryar E. Mir,Philip C. De Witt Hamer,Przemek M. Krawczyk,Leonora Balaj,An Claes,Johanna M. Niers,Johanna M. Niers,Angela A.G. van Tilborg,Aeilko H. Zwinderman,Dirk Geerts,Gertjan J.L. Kaspers,W. Peter Vandertop,Jacqueline Cloos,Bakhos A. Tannous,Pieter Wesseling,Jacob A. Aten,David P. Noske,Cornelis J.F. Van Noorden,Thomas Wurdinger,Thomas Wurdinger +19 more
TL;DR: It is demonstrated that WEE1 is a major regulator of the G(2) checkpoint in glioblastoma cells, and it is shown that the small-molecule inhibitor of Wee1 sensitizes gliOBlastoma to ionizing radiation in vivo.
Journal ArticleDOI
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
Michiel Smits,Jonas Nilsson,Shahryar E. Mir,Petra van der Stoop,Esther Hulleman,Johanna M. Niers,Phillip C. de Witt Hamer,Victor E. Marquez,Jacqueline Cloos,Anna M. Krichevsky,David P. Noske,Bakhos A. Tannous,Thomas Wurdinger +12 more
TL;DR: The results indicate that EZH2 has a versatile function in GBM progression and that its overexpression is at least partly due to decreased miR-101 expression, which may be a potential therapeutic strategy to target GBM proliferation, migration, and angiogenesis.
Journal ArticleDOI
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.