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Anton F.P.M. de Goeij
Researcher at Maastricht University
Publications - 49
Citations - 4060
Anton F.P.M. de Goeij is an academic researcher from Maastricht University. The author has contributed to research in topics: Colorectal cancer & Diet and cancer. The author has an hindex of 33, co-authored 49 publications receiving 3825 citations. Previous affiliations of Anton F.P.M. de Goeij include Maastricht University Medical Centre.
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Journal ArticleDOI
Surviving in a Marine Desert: The Sponge Loop Retains Resources Within Coral Reefs
Jasper M. de Goeij,Dick van Oevelen,Mark J. A. Vermeij,Ronald Osinga,Jack J. Middelburg,Anton F.P.M. de Goeij,Wim Admiraal +6 more
TL;DR: The DOM-sponge-fauna pathway explains why biological hot spots such as coral reefs persist in oligotrophic seas—the reef’s paradox—and has implications for reef ecosystem functioning and conservation strategies.
Journal ArticleDOI
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability
Mario Hermsen,Cindy Postma,Jan P. A. Baak,Marjan M. Weiss,A. Rapallo,Andrea Sciutto,Guido M.J.M. Roemen,Jan Willem Arends,Richard A. Williams,Walter Giaretti,Anton F.P.M. de Goeij,Gerrit A. Meijer +11 more
TL;DR: Evidence was found that these chromosomal abnormalities occurred in specific combinations of a few abnormalities rather than as a mere accumulation of events, indicating the existence of multiple independent chromosomal instability pathways of colorectal cancer progression.
Journal ArticleDOI
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Mirian Brink,Anton F.P.M. de Goeij,Matty P. Weijenberg,Guido M.J.M. Roemen,Marjolein H.F.M. Lentjes,Marco M.M. Pachen,Kim M. Smits,Adriaan P. de Bruïne,R. Alexandra Goldbohm,Piet A. van den Brandt +9 more
TL;DR: The equal distribution of K-ras mutations among cases with or without a family history of colorectal cancer argues against an important role for this mutation in familial coloreCTal cancer, and could imply that K-ra mutations are more probably involved in environmental mechanisms of colOREctal carcinogenesis.
Journal Article
Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer.
Manon van Engeland,Matty P. Weijenberg,Guido M.J.M. Roemen,Mirian Brink,Adriaan P. de Bruïne,R. Alexandra Goldbohm,Piet A. van den Brandt,Stephen B. Baylin,Anton F.P.M. de Goeij,James G. Herman +9 more
TL;DR: F folate and alcohol intake may be associated with changes in promoter hypermethylation in CRC, and the number of CRCs with at least one gene methylated was higher in the low folate intake/high alcohol intake group when compared with the high folate Intake/low alcohol Intake group.
Journal ArticleDOI
In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low‐grade serous tumours
Nathalie L.G. Sieben,Patricia Macropoulos,Guido M.J.M. Roemen,Sandra M. Kolkman-Uljee,Gert Jan Fleuren,Rifat Houmadi,Tim C. Diss,Bretta Warren,Mudher Al Adnani,Anton F.P.M. de Goeij,Thomas Krausz,Adrienne M. Flanagan +11 more
TL;DR: The finding that at least 60% of serous borderline tumours harbour mutations in two members of the ERK‐MAP‐kinase pathway compared with 12% of high‐grade serous carcinomas (BRAF 0%, KRAS 12%) indicates that the majority of serious borderline tumoured tumours do not progress to serious carcinomas.