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Antonella Capozzi

Researcher at Sapienza University of Rome

Publications -  60
Citations -  1245

Antonella Capozzi is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Antiphospholipid syndrome & Lipid raft. The author has an hindex of 16, co-authored 51 publications receiving 959 citations.

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Anti-β2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor α and tissue factor by signal transduction pathways involving lipid rafts

TL;DR: New insight is provided into the pathogenesis of APS and anti-β2GPI antibodies react with their target antigen, likely in association with annexin A2 and TLR-4, in lipid rafts in the monocyte plasma membrane, improving the knowledge of valuable therapeutic targets.
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Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome.

TL;DR: It is demonstrated that affinity-purified antivimentin/cardiolipin antibodies induced interleukin receptor-associated kinase phosphorylation and nuclear factor-κB activation in endothelial cells.
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Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies

TL;DR: In vitro results support the view that the processing of proteins in autophagy generates citrullinated peptides recognized by the immune system in RA, and a significant association between levels of autophile and anti-CCP Abs was observed in treatment-naïve early-active RA patients.
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Advanced glycation end products of human β2 glycoprotein I modulate the maturation and function of DCs

TL;DR: This study explored whether glucose-modified β₂GPI is able to interact and activate monocyte-derived immature dendritic cells (iDCs) from healthy human donors and found that it caused phenotypical and functional maturation of iDCs involving the activation of p38 MAPK, ERK, and NF-κB.