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Antonella Capozzi
Researcher at Sapienza University of Rome
Publications - 60
Citations - 1245
Antonella Capozzi is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Antiphospholipid syndrome & Lipid raft. The author has an hindex of 16, co-authored 51 publications receiving 959 citations.
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Journal ArticleDOI
Autoantibodies specific to a peptide of β2-glycoprotein I cross-react with TLR4, inducing a proinflammatory phenotype in endothelial cells and monocytes
Tania Colasanti,Cristiano Alessandri,Antonella Capozzi,Maurizio Sorice,Federica Delunardo,Agostina Longo,Marina Pierdominici,Fabrizio Conti,Simona Truglia,Alessandra Siracusano,Guido Valesini,Elena Ortona,Paola Margutti +12 more
TL;DR: A novel pathogenic mechanism in the TLR4 stimulation by anti-β(2)GPI peptide Abs that links adaptive immune responses with innate immunity in antiphospholipid syndrome and systemic lupus erythematosus is suggested.
Journal ArticleDOI
The Mosaic of “Seronegative” Antiphospholipid Syndrome
Fabrizio Conti,Antonella Capozzi,Simona Truglia,Emanuela Lococo,Agostina Longo,Roberta Misasi,Cristiano Alessandri,Guido Valesini,Maurizio Sorice +8 more
TL;DR: Findings suggest that in sera from patients with SN-APS, antibodies may be detected using “new” antigenic targets (mainly vimentin/cardiolipin) or methodological approaches different from traditional techniques (Mainly TLC immunostaining).
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Subclinical atherosclerosis in systemic lupus erythematosus and antiphospholipid syndrome: focus on β2GPI-specific T cell response
Fabrizio Conti,Francesca Romana Spinelli,Cristiano Alessandri,Massimo Pacelli,Fulvia Ceccarelli,E. Marocchi,Anna Montali,Antonella Capozzi,Brigitta Buttari,Elisabetta Profumo,Maurizio Sorice,Marcello Arca,Guido Valesini,Rachele Riganò +13 more
TL;DR: A significant percentage of patients with SLE and PAPS show a &bgr;2GPI-specific T cell reactivity, which is associated with subclinical atherosclerosis, and this work confirms a link between autoimmunity and endothelial dysfunction.
Journal ArticleDOI
New antigenic targets and methodological approaches for refining laboratory diagnosis of antiphospholipid syndrome
Roberta Misasi,Antonella Capozzi,Agostina Longo,Serena Recalchi,Emanuela Lococo,Cristiano Alessandri,Fabrizio Conti,Guido Valesini,Maurizio Sorice +8 more
TL;DR: Recent findings suggest that, in sera from patients with SN-APS, antibodies may be detected using “new” antigenic targets (mainly vimentin/cardiolipin) or methodological approaches different from traditional techniques (TLC immunostaining).
Journal ArticleDOI
Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer's disease.
Davide Vacirca,Federica Delunardo,Paola Matarrese,Tania Colasanti,Paola Margutti,Alessandra Siracusano,Simona Pontecorvo,Antonella Capozzi,Maurizio Sorice,Ada Francia,Walter Malorni,Elena Ortona +11 more
TL;DR: Findings suggest that autoantibodies specific to ATP synthase can exert a pathogenetic role via a mechanism that brings into play the impairment of the extracellular ATP homeostasis and the alteration of mitochondrial function triggering cell death by apoptosis.