Antonella Capozzi

TL;DR: It is demonstrated that anti‐β2‐GPI antibodies may trigger in vitro a signal transduction pathway in human platelets, which involves IRAK phosphorylation and NF‐κB activation, followed by TF expression.

TL;DR: Autophagy is able to induce in vitro carbamylation processes, and in vivo appears to be related to an increase in carbamyation during RA, which introduces a new pathogenetic mechanism of disease, which could contribute to more accurate monitoring of patients.

TL;DR: Serum levels of HMGB1, an alarmin which plays a pivotal role in inducing and enhancing immune cell function, are analyzed in patients with antiphospholipid syndrome and subjects with pregnancy morbidity to suggest that in subjects withregnancy morbidity, elevated levels ofHMGB1/sRAGE may represent an alarm signal, indicating an increase of proinflammatory triggers.

TL;DR: Collective findings indicate that prosaposin is not a simple house-keeping precursor protein; instead, it is a protein essentially required for the development and maintenance of the central and peripheral nervous systems.

TL;DR: A massive redistribution of this protein in the cytoplasm of endothelial and neuronal cells in apoptosis is demonstrated and identified RABPT5 as a novel autoantigen in AD.