A
Antonella Capozzi
Researcher at Sapienza University of Rome
Publications - 60
Citations - 1245
Antonella Capozzi is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Antiphospholipid syndrome & Lipid raft. The author has an hindex of 16, co-authored 51 publications receiving 959 citations.
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Anti-β2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor α and tissue factor by signal transduction pathways involving lipid rafts
Maurizio Sorice,Agostina Longo,Antonella Capozzi,Tina Garofalo,Roberta Misasi,Cristiano Alessandri,Fabrizio Conti,Brigitta Buttari,Rachele Riganò,Elena Ortona,Guido Valesini +10 more
TL;DR: New insight is provided into the pathogenesis of APS and anti-β2GPI antibodies react with their target antigen, likely in association with annexin A2 and TLR-4, in lipid rafts in the monocyte plasma membrane, improving the knowledge of valuable therapeutic targets.
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Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome.
Elena Ortona,Antonella Capozzi,Tania Colasanti,Fabrizio Conti,Cristiano Alessandri,Agostina Longo,Tina Garofalo,Paola Margutti,Roberta Misasi,Munther A. Khamashta,Graham R. V. Hughes,Guido Valesini,Maurizio Sorice +12 more
TL;DR: It is demonstrated that affinity-purified antivimentin/cardiolipin antibodies induced interleukin receptor-associated kinase phosphorylation and nuclear factor-κB activation in endothelial cells.
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Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis.
Paola Margutti,Paola Matarrese,Fabrizio Conti,Tania Colasanti,Federica Delunardo,Antonella Capozzi,Tina Garofalo,Elisabetta Profumo,Rachele Riganò,Alessandra Siracusano,Cristiano Alessandri,Bruno Salvati,Guido Valesini,Walter Malorni,Maurizio Sorice,Elena Ortona +15 more
TL;DR: It is suggested that autoantibodies to RLIP76 play a pathogenetic role in immune- mediated vascular diseases and represent a valuable peripheral blood bioindicator of atherosclerosis and immune-mediated vascular diseases.
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Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies
Maurizio Sorice,Cristina Iannuccelli,Valeria Manganelli,Antonella Capozzi,Cristiano Alessandri,Emanuela Lococo,Tina Garofalo,Manuela Di Franco,Michele Bombardieri,Alessandra Nerviani,Roberta Misasi,Guido Valesini +11 more
TL;DR: In vitro results support the view that the processing of proteins in autophagy generates citrullinated peptides recognized by the immune system in RA, and a significant association between levels of autophile and anti-CCP Abs was observed in treatment-naïve early-active RA patients.
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Advanced glycation end products of human β2 glycoprotein I modulate the maturation and function of DCs
Brigitta Buttari,Elisabetta Profumo,Antonella Capozzi,Francesco Facchiano,Luciano Saso,Maurizio Sorice,Rachele Riganò +6 more
TL;DR: This study explored whether glucose-modified β₂GPI is able to interact and activate monocyte-derived immature dendritic cells (iDCs) from healthy human donors and found that it caused phenotypical and functional maturation of iDCs involving the activation of p38 MAPK, ERK, and NF-κB.