A
Anu Suomalainen
Researcher at University of Helsinki
Publications - 214
Citations - 19456
Anu Suomalainen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrial disease. The author has an hindex of 67, co-authored 206 publications receiving 17041 citations. Previous affiliations of Anu Suomalainen include Montreal Neurological Institute and Hospital & University of Eastern Finland.
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Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers.
Jana Buzkova,Joni Nikkanen,Sofia Ahola,Anna H. Hakonen,Ksenia Sevastianova,Ksenia Sevastianova,Topi Hovinen,Hannele Yki-Järvinen,Hannele Yki-Järvinen,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Tuula Lönnqvist,Vidya Velagapudi,Christopher Carroll,Christopher Carroll,Anu Suomalainen +15 more
TL;DR: The omics approach identified pathways currently used to treat NMDs and mitochondrial stroke‐like episodes and proposes nicotinamide riboside in MDs and IBM, and creatine in IOSCA and IBM as novel treatment targets.
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Next-generation sequencing for mitochondrial disorders
TL;DR: The strategies and findings from studies applying next‐generation sequencing methods for the genetic diagnosis of mitochondrial disorders, and detailed knowledge of molecular causes also enables collection of homogenous cohorts of patients for therapy trials, and therefore boosts development of intervention.
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Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation
Liliya Euro,Svetlana Konovalova,Jorge Asin-Cayuela,Már Tulinius,Helen Griffin,Rita Horvath,Robert W. Taylor,Patrick F. Chinnery,Ulrike Schara,David R. Thorburn,Anu Suomalainen,Anu Suomalainen,Joseph Chihade,Henna Tyynismaa +13 more
TL;DR: This model predicts that the cardiomyopathy mutations severely compromise aminoacylation whereas partial activity is retained by the mutation combinations found in the leukodystrophy patients, and provides a hypothesis for the molecular basis of the distinct tissue-specific phenotypic outcomes.
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Biomarkers for mitochondrial respiratory chain disorders.
TL;DR: Identified molecular signals or metabolic fingerprints have the potential to be highly useful biomarkers for future diagnosis of mitochondrial respiratory chain disorders.
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MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction
Kati J. Ahlqvist,Silvia Leoncini,Alessandra Pecorelli,Saskia B. Wortmann,Sofia Ahola,Saara Forsström,Roberto Guerranti,C De Felice,Jan A.M. Smeitink,Lucia Ciccoli,Riikka H. Hämäläinen,Anu Suomalainen +11 more
TL;DR: It is shown that elevated mtDNA mutagenesis in mice with a proof-reading deficient mtDNA polymerase (PolG) leads to incomplete mitochondrial clearance, with asynchronized iron loading in erythroid precursors, and increased total and free cellular iron content.