A
Anu Suomalainen
Researcher at University of Helsinki
Publications - 214
Citations - 19456
Anu Suomalainen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrial disease. The author has an hindex of 67, co-authored 206 publications receiving 17041 citations. Previous affiliations of Anu Suomalainen include Montreal Neurological Institute and Hospital & University of Eastern Finland.
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Journal ArticleDOI
Toward Cloning of a Novel Ataxia Gene: Refined Assignment and Physical Map of the IOSCA Locus (SCA8) on 10q24
TL;DR: Haplotype analysis combined with genealogical data provided evidence that all the IOSCA cases in Finland originate from a single 30- to 40-generation-old founder mutation, suggesting the isolation of a novel ataxia gene.
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RNA modification landscape of the human mitochondrial tRNA(LYs) regulates protein synthesis
Uwe Richter,Molly E. Evans,Wesley C. Clark,Paula Marttinen,Eric A. Shoubridge,Anu Suomalainen,Anna Wredenberg,Anna Wedell,Tao Pan,Brendan J. Battersby +9 more
TL;DR: The role of a N1 -methyladenosine modification is revealed in tRNALys MERR patients for translation elongation and the stability of selected nascent chains and indicates regulation of post-transcriptional modifications on mitochondrial tRNAs is finely tuned for the control of mitochondrial gene expression.
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Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients.
Sofia Ahola,Mari Auranen,Pirjo Isohanni,Satu Niemisalo,Niina Urho,Jana Buzkova,Vidya Velagapudi,Nina Lundbom,Antti Hakkarainen,Tiina Muurinen,Päivi Piirilä,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Anu Suomalainen +13 more
TL;DR: Results indicate that nutrition can modify mitochondrial disease progression, dietary counseling should be part of MM care, short mAD is a tool to induce targeted RRF lysis, and mAD, a common weight‐loss method, may induce muscle damage in a population subgroup.
Journal ArticleDOI
POLG1 manifestations in childhood
Pirjo Isohanni,Anna H. Hakonen,Liliya Euro,Ilse Paetau,Tarja Linnankivi,Elina Liukkonen,Tiina Wallden,L. Luostarinen,Leena Valanne,Anders Paetau,Johanna Uusimaa,Tuula Lönnqvist,Anu Suomalainen,Helena Pihko +13 more
TL;DR: POLG1 analysis should belong to the first-line DNA diagnostic tests for children with an encephalitis-like presentation evolving into epileptic encephalopathy with liver involvement (Alpers syndrome), even if brain MRI and morphology, respiratory chain activities, and the amount of mitochondrial DNA in the skeletal muscle are normal.
Liver Fat But Not Other Adiposity Measures Influence Circulating FGF21 Levels in Healthy Young Adult Twins
Henna Tyynismaa,Taneli Raivio,Antti Hakkarainen,Alfredo Ortega-Alonso,Nina Lundbom,Jaakko Kaprio,Jaakko Kaprio,Aila Rissanen,Anu Suomalainen,Anu Suomalainen,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen +11 more
TL;DR: Within-pair differences in liver fat (MZ) and triglycerides (dizygotic pairs) were the major acquired factors that correlated with differences in FGF21 concentrations, and genetic factors influence serum F GF21 levels.