A
Anu Suomalainen
Researcher at University of Helsinki
Publications - 214
Citations - 19456
Anu Suomalainen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrial disease. The author has an hindex of 67, co-authored 206 publications receiving 17041 citations. Previous affiliations of Anu Suomalainen include Montreal Neurological Institute and Hospital & University of Eastern Finland.
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New treatments for mitochondrial disease—no time to drop our standards
Gerald Pfeffer,Rita Horvath,Thomas Klopstock,Vamsi K. Mootha,Anu Suomalainen,Saskia Koene,Michio Hirano,Massimo Zeviani,Laurence A. Bindoff,Patrick Yu-Wai-Man,Michael G. Hanna,Valerio Carelli,Robert McFarland,Kari Majamaa,Douglas M. Turnbull,Jan A.M. Smeitink,Patrick F. Chinnery +16 more
TL;DR: Recommendations are made for the design of future treatment trials in mitochondrial diseases that should no longer rely on potentially biased data, with the associated costs and risks.
Journal ArticleDOI
Mitochondrial phenylalanyl-tRNA synthetase mutations underlie fatal infantile Alpers encephalopathy
Jenni M. Elo,Srujana S. Yadavalli,Liliya Euro,Pirjo Isohanni,Alexandra Götz,Christopher Carroll,Leena Valanne,Fowzan S. Alkuraya,Fowzan S. Alkuraya,Johanna Uusimaa,Anders Paetau,Eric M. Caruso,Helena Pihko,Michael Ibba,Henna Tyynismaa,Anu Suomalainen,Anu Suomalainen +16 more
TL;DR: A new genetic cause of infantile mitochondrial Alpers encephalopathy is established and a new mitochondrial aminoacyl-tRNA synthetase as a cause of mitochondrial disease is reported.
Journal ArticleDOI
Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.
Susa Enholm,Tuija Hienonen,Anu Suomalainen,Lara Lipton,Ian Tomlinson,Vesa Kärjä,Matti Eskelinen,Jukka-Pekka Mecklin,Auli Karhu,Heikki Järvinen,Lauri A. Aaltonen +10 more
TL;DR: Y165C and G382D variants were not present in 424 Finnish cancer-free controls showing that MYH mutations are not enriched in the population, and MYH-associated colorectal cancer appears to be as common as coloreCTal cancer associated with familial adenomatous polyposis.
Journal ArticleDOI
Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions
Saara Forsström,Christopher B. Jackson,Christopher Carroll,Christopher Carroll,Mervi Kuronen,Eija Pirinen,Swagat Pradhan,Anastasiia Marmyleva,Mari Auranen,Iida-Marja Kleine,Nahid Akhtar Khan,Anne Roivainen,Päivi Marjamäki,Heidi Liljenbäck,Liya Wang,Brendan J. Battersby,Uwe Richter,Vidya Velagapudi,Joni Nikkanen,Liliya Euro,Anu Suomalainen,Anu Suomalainen +21 more
TL;DR: The evidence indicates that FGF21 is a local and systemic messenger of mtDNA stress in mice and humans with mitochondrial disease, and drives weight loss and glucose preference, and modifies metabolism and respiratory chain deficiency in a specific hippocampal brain region.
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Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease
Petri Luoma,J. Eerola,Sofia Ahola,Anna H. Hakonen,O. Hellström,Kari T. Kivistö,Pentti J. Tienari,Anu Suomalainen +7 more
TL;DR: The results suggest that POLG polyglutamine tract variants should be considered as a predisposing genetic factor in idiopathic sporadic Parkinson disease.