Gustavo Martinez-Delgado

TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.

TL;DR: In this article, the authors report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection with SARS-CoV-2.

TL;DR: The memory B cell response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence, and the antibodies they express have greater somatic hypermutation, increased potency and resistance to RBD mutations, indicative of continued evolution of the humoral response.

TL;DR: Serine 8 phosphorylation at the first CARD of RIG-I is reported as a negative regulatory mechanism of Rig-I-mediated IFN-β production and sequence comparison reveals that only primate species carry serine 8, whereas other animal species carry an asparagine, indicating that serine 7 phosphorylated may represent a primate-specific regulation of R IG-I activation.

TL;DR: In this article, the authors investigated intestinal infection with SARS-CoV-2, its effect on pathogenesis, and clinical significance, and found a significant reduction in disease severity and mortality in patients presenting with GI symptoms that was independent of sex, age, and comorbid illnesses.