A
Ashit Trivedi
Researcher at Amgen
Publications - 28
Citations - 377
Ashit Trivedi is an academic researcher from Amgen. The author has contributed to research in topics: Cmax & Pharmacokinetics. The author has an hindex of 6, co-authored 24 publications receiving 299 citations. Previous affiliations of Ashit Trivedi include University of Tennessee Health Science Center.
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Journal ArticleDOI
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Richard E. Lee,Julian G. Hurdle,Jiuyu Liu,David F. Bruhn,Tanja Matt,Michael S. Scherman,Pavan K. Vaddady,Zhong Zheng,Jianjun Qi,Rashid Akbergenov,Sourav Das,Dora B. Madhura,Chetan Rathi,Ashit Trivedi,Cristina Villellas,Robin B. Lee,Rakesh,Samanthi L. Waidyarachchi,Dianqing Sun,Michael R. McNeil,José A. Aínsa,Helena I. Boshoff,Mercedes Gonzalez-Juarrero,Bernd Meibohm,Erik C. Böttger,Anne J. Lenaerts +25 more
TL;DR: The antitubercular efficacy of spectinamides demonstrates that synthetic modifications to classical antibiotics can overcome the challenge of intrinsic efflux pump-mediated resistance and expands opportunities for target-based tuberculosis drug discovery.
Journal ArticleDOI
Clinical Pharmacology and Translational Aspects of Bispecific Antibodies.
Ashit Trivedi,S Stienen,Min Zhu,H Li,Theresa Yuraszeck,John P. Gibbs,John P. Gibbs,Timothy G. Heath,R Loberg,Sreeneeranj Kasichayanula,Sreeneeranj Kasichayanula +10 more
TL;DR: This review discusses challenges, and suggestions to overcome them, associated with the development of BsAbs, specifically those pertaining to clinical pharmacology, pharmacometrics, and bioanalysis.
Journal ArticleDOI
Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties
Rakesh,David F. Bruhn,Dora B. Madhura,Marcus M. Maddox,Robin B. Lee,Ashit Trivedi,Lei Yang,Michael S. Scherman,Janet C. Gilliland,Veronica Gruppo,Michael R. McNeil,Anne J. Lenaerts,Bernd Meibohm,Richard E. Lee +13 more
TL;DR: Overall, the addition of solubilizing and metabolically blocked outer rings did improve solubility and decrease protein binding as designed, however, the metabolic stability for compounds in this series was generally lower than desired.
Journal ArticleDOI
Reverse Translation of US Food and Drug Administration Reviews of Oncology New Molecular Entities Approved in 2011–2017: Lessons Learned for Anticancer Drug Development
TL;DR: Results from studies evaluating food effect, QTc prolongation, drug-drug interactions, renal and hepatic impairment effects, and dose optimization, as well as postmarketing requirements/commitments, were reviewed.
Journal ArticleDOI
Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives.
TL;DR: This review highlights the usefulness of pharmacometric analyses in anti-infective drug development and applied pharmacotherapy with select examples.