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Dianqing Sun
Researcher at University of Hawaii at Hilo
Publications - 59
Citations - 1603
Dianqing Sun is an academic researcher from University of Hawaii at Hilo. The author has contributed to research in topics: Topoisomerase & Solid-phase synthesis. The author has an hindex of 19, co-authored 57 publications receiving 1326 citations. Previous affiliations of Dianqing Sun include University of Hawaii & University of Tennessee Health Science Center.
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Journal ArticleDOI
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles
Xufen Yu,Dianqing Sun +1 more
TL;DR: The primary goal of this review is to summarize currently used macrocyclic drugs, highlight the therapeutic potential of this underexplored drug class and outline the general synthetic methodologies for the synthesis of macrocycles.
Journal ArticleDOI
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Richard E. Lee,Julian G. Hurdle,Jiuyu Liu,David F. Bruhn,Tanja Matt,Michael S. Scherman,Pavan K. Vaddady,Zhong Zheng,Jianjun Qi,Rashid Akbergenov,Sourav Das,Dora B. Madhura,Chetan Rathi,Ashit Trivedi,Cristina Villellas,Robin B. Lee,Rakesh,Samanthi L. Waidyarachchi,Dianqing Sun,Michael R. McNeil,José A. Aínsa,Helena I. Boshoff,Mercedes Gonzalez-Juarrero,Bernd Meibohm,Erik C. Böttger,Anne J. Lenaerts +25 more
TL;DR: The antitubercular efficacy of spectinamides demonstrates that synthetic modifications to classical antibiotics can overcome the challenge of intrinsic efflux pump-mediated resistance and expands opportunities for target-based tuberculosis drug discovery.
Journal ArticleDOI
Recent synthetic developments and applications of the ullmann reaction. a review
Hao Lin,Dianqing Sun +1 more
TL;DR: This work describes the development of Ullmann-type Reactions in Heterocyclic, Medicinal, and Natural Products Chemistry and some of the applications of these Reactions have been found to be beneficial to human health and the environment.
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The structure-activity relationship of urea derivatives as anti-tuberculosis agents
Joshua R. Brown,Elton J. North,Julian G. Hurdle,Christophe Morisseau,Jerrod S. Scarborough,Dianqing Sun,Jana Korduláková,Michael S. Scherman,Victoria Jones,Anna E. Grzegorzewicz,Rebecca Crew,Mary Jackson,Michael R. McNeil,Richard E. Lee +13 more
TL;DR: The direct anti-tubercular testing of a small compound library led to discovery of adamantyl urea hit compound 1 and the synthesis of an optimization library, noting that the compounds identified and the pharmacophore developed is consistent with inhibitors of epoxide hydrolase family of enzymes.
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Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives
Li Feng,Marcus M. Maddox,Zahidul Alam,Lissa S. Tsutsumi,Gagandeep Narula,David F. Bruhn,Xiaoqian Wu,Shayna Sandhaus,Robin B. Lee,Charles J. Simmons,Yuk-Ching Tse-Dinh,Julian G. Hurdle,Richard E. Lee,Dianqing Sun +13 more
TL;DR: Mode of action studies performed on selected compounds revealed that they dissipated the bacterial membrane potential, resulting in the inhibition of macromolecular biosynthesis; further studies showed that selected compounds inhibited DNA topoisomerase IV, suggesting complex mechanisms of actions for compounds in this series.