A
Athanassios Vassilopoulos
Researcher at Northwestern University
Publications - 39
Citations - 4967
Athanassios Vassilopoulos is an academic researcher from Northwestern University. The author has contributed to research in topics: Sirtuin & SIRT2. The author has an hindex of 24, co-authored 39 publications receiving 4327 citations. Previous affiliations of Athanassios Vassilopoulos include National and Kapodistrian University of Athens & Veterans Health Administration.
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Journal ArticleDOI
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Bong-Hyun Ahn,Hyun-Seok Kim,Shiwei Song,In Hye Lee,Jie Liu,Athanassios Vassilopoulos,Chu-Xia Deng,Toren Finkel +7 more
TL;DR: It is shown that Sirt3 functions in vivo to regulate and maintain basal ATP levels and as a regulator of mitochondrial electron transport and implicate protein acetylation as an important regulator of Complex I activity.
Journal ArticleDOI
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim,Krish Patel,Kristi Muldoon-Jacobs,Kheem S. Bisht,Nukhet Aykin-Burns,J. Daniel Pennington,Riet van der Meer,Phuongmai Nguyen,Jason E. Savage,Kjerstin M. Owens,Athanassios Vassilopoulos,Özkan Özden,Seong Hoon Park,Keshav K. Singh,Sarki A. Abdulkadir,Douglas R. Spitz,Chu-Xia Deng,David Gius +17 more
TL;DR: These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor and human breast and other human cancer specimens exhibit reduced Sirt3 levels.
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SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity
Hyun-Seok Kim,Athanassios Vassilopoulos,Rui Hong Wang,Tyler Lahusen,Zhen Xiao,Xiaoling Xu,Cuiling Li,Timothy D. Veenstra,Bing Li,Hongtao Yu,Junfang Ji,Xin Wei Wang,Seong Hoon Park,Yong I. Cha,David Gius,Chu-Xia Deng +15 more
TL;DR: It is demonstrated that SIRT2 regulates the anaphase-promoting complex/cyclosome activity through deacetylation of its coactivators, APC(CDH1) and CDC20, and is a tumor suppressor through its role in regulating mitosis and genome integrity.
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Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
Hyun-Seok Kim,Cuiying Xiao,Rui Hong Wang,Tyler Lahusen,Xiaoling Xu,Athanassios Vassilopoulos,Guelaguetza Vázquez-Ortiz,Won-Il Jeong,Ogyi Park,Sung Hwan Ki,Bin Gao,Chu-Xia Deng +11 more
TL;DR: It is shown that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT 6, which negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone Lysine 9 in the promoter of many genes involved in these processes.
Journal ArticleDOI
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Rui Hong Wang,Yin Zheng,Hyun-Seok Kim,Xiaoling Xu,Liu Cao,Tyler Luhasen,Mi Hye Lee,Cuiying Xiao,Athanassios Vassilopoulos,Weiping Chen,Kevin Gardner,Yan Gao Man,Mien Chie Hung,Toren Finkel,Chu-Xia Deng +14 more
TL;DR: It is demonstrated that activation of Sirt1 and inhibition of Survivin expression by resveratrol elicit a more profound inhibitory effect onBrca1 mutant cancer cells than on Brca1-wild-type cancer cells both in vitro and in vivo.