K
Kristi Muldoon-Jacobs
Researcher at Food and Drug Administration
Publications - 8
Citations - 1831
Kristi Muldoon-Jacobs is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 6, co-authored 8 publications receiving 1731 citations. Previous affiliations of Kristi Muldoon-Jacobs include National Institutes of Health & Center for Food Safety and Applied Nutrition.
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Journal ArticleDOI
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu,David Gius,Patrick Onyango,Kristi Muldoon-Jacobs,Judith E. Karp,Andrew P. Feinberg,Hengmi Cui +6 more
TL;DR: It is shown that many TSGs have nearby antisense RNAs, and an inverse relation between p15 antisense (p15AS) and p15 sense expression in leukaemia is found, which suggests natural antisense RNA may be a trigger for heterochromatin formation and DNA methylation in TSG silencing in tumorigenesis.
Journal ArticleDOI
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim,Krish Patel,Kristi Muldoon-Jacobs,Kheem S. Bisht,Nukhet Aykin-Burns,J. Daniel Pennington,Riet van der Meer,Phuongmai Nguyen,Jason E. Savage,Kjerstin M. Owens,Athanassios Vassilopoulos,Özkan Özden,Seong Hoon Park,Keshav K. Singh,Sarki A. Abdulkadir,Douglas R. Spitz,Chu-Xia Deng,David Gius +17 more
TL;DR: These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor and human breast and other human cancer specimens exhibit reduced Sirt3 levels.
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Epigenetic targets of some toxicologically relevant metals: a review of the literature.
TL;DR: Recent studies that investigate the epigenetic, gene expression, and biological effects of various inorganic and organic forms of heavy metals, such as cadmium, arsenic, nickel, chromium, methylmercury, lead, copper and organotin compounds are reviewed.
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DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells.
Mark Mishra,Kheem S. Bisht,Lunching Sun,Kristi Muldoon-Jacobs,Rania T. Awwad,Aradhana Kaushal,Phuongmai Nguyen,Lei Huang,J. Daniel Pennington,Stephanie Markovina,C. Matthew Bradbury,David Gius +11 more
TL;DR: This work is the first example of a role for the epigenome in tumor cell resistance to the cytotoxicity of exogenous oxidative (H2O2) or systemic (etoposide and cisplatin) agents and highlights a potential role for DNMT1 as a potential molecular target in cancer therapy.
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Infant toxicology: state of the science and considerations in evaluation of safety.
April Neal-Kluever,Jason Aungst,Yan Gu,Karen Hatwell,Kristi Muldoon-Jacobs,Ayesha Liem,Adejoke Ogungbesan,M.E. Shackelford +7 more
TL;DR: The purpose of this document is to review key biological and exposure elements that may impact the evaluation of safety for food contact products intended for use by infants, summarize the current reproductive and developmental toxicity testing protocols available, and identify potential data gaps concerning this period of development.