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Seong Hoon Park
Researcher at Hallym University
Publications - 73
Citations - 3499
Seong Hoon Park is an academic researcher from Hallym University. The author has contributed to research in topics: Sirtuin & SIRT2. The author has an hindex of 19, co-authored 66 publications receiving 3048 citations. Previous affiliations of Seong Hoon Park include Veterans Health Administration & Vanderbilt University Medical Center.
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Journal ArticleDOI
Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
Randa Tao,Mitchell C. Coleman,J. Daniel Pennington,Özkan Özden,Seong Hoon Park,Haiyan Jiang,Hyun Seok Kim,Charles R. Flynn,Salisha Hill,W. Hayes McDonald,Alicia K. Olivier,Douglas R. Spitz,David Gius +12 more
TL;DR: Infestation of Sirt3⁻/⁻ MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide, suggesting acetylation directly regulates function.
Journal ArticleDOI
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim,Krish Patel,Kristi Muldoon-Jacobs,Kheem S. Bisht,Nukhet Aykin-Burns,J. Daniel Pennington,Riet van der Meer,Phuongmai Nguyen,Jason E. Savage,Kjerstin M. Owens,Athanassios Vassilopoulos,Özkan Özden,Seong Hoon Park,Keshav K. Singh,Sarki A. Abdulkadir,Douglas R. Spitz,Chu-Xia Deng,David Gius +17 more
TL;DR: These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor and human breast and other human cancer specimens exhibit reduced Sirt3 levels.
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SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity
Hyun-Seok Kim,Athanassios Vassilopoulos,Rui Hong Wang,Tyler Lahusen,Zhen Xiao,Xiaoling Xu,Cuiling Li,Timothy D. Veenstra,Bing Li,Hongtao Yu,Junfang Ji,Xin Wei Wang,Seong Hoon Park,Yong I. Cha,David Gius,Chu-Xia Deng +15 more
TL;DR: It is demonstrated that SIRT2 regulates the anaphase-promoting complex/cyclosome activity through deacetylation of its coactivators, APC(CDH1) and CDC20, and is a tumor suppressor through its role in regulating mitosis and genome integrity.
Journal ArticleDOI
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.
Özkan Özden,Seong Hoon Park,Brett A. Wagner,Ha Yong Song,Yueming Zhu,Athanassios Vassilopoulos,Barbara Jung,Garry R. Buettner,David Gius +8 more
TL;DR: The results suggest that the acetylation of PDHA1 provides another layer of enzymatic regulation, in addition to phosphorylation, involving a reversible acetyllysine, suggesting that theacetylome, as well as the kinome, links glycolysis to respiration.
Journal ArticleDOI
Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress
Özkan Özden,Seong Hoon Park,Hyun Seok Kim,Haiyan Jiang,Mitchell C. Coleman,Douglas R. Spitz,David Gius +6 more
TL;DR: It is suggested for the first time, that the mitochondria contain bidirectional post-translational signaling networks, similar to that observed in the cytoplasm and nucleus, and that changes in lysine acetylation alter MnSOD enzymatic activity.