A
Audesh Bhat
Researcher at University of Jammu
Publications - 49
Citations - 1334
Audesh Bhat is an academic researcher from University of Jammu. The author has contributed to research in topics: Oxidative stress & Medicine. The author has an hindex of 16, co-authored 41 publications receiving 1115 citations. Previous affiliations of Audesh Bhat include Jawaharlal Nehru University & University of Saskatchewan.
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The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.
Brendan Jones,Hui Su,Audesh Bhat,Hong Lei,Jeffrey Bajko,Sarah Hevi,Gretchen A. Baltus,Shilpa Kadam,Huili Zhai,Reginald Valdez,Susana Gonzalo,Yi Zhang,Yi Zhang,En Li,Taiping Chen +14 more
TL;DR: Results indicate that Dot1L and H3K79 methylation play important roles in heterochromatin formation and in embryonic development.
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Mitochondrial DNA G10398A polymorphism imparts maternal Haplogroup N a risk for breast and esophageal cancer
TL;DR: This study makes an attempt to validate the exclusive presence of mtG10398A (Ala-->Thr) polymorphism in a haplotype constituting mtDNA haplogroup N and its sublineages, imparting this group a higher risk for breast cancer, based on the re-analyses of approximately 1000 complete human mtDNA sequences worldwide and collated information on 2334 individuals belonging to 18 regions in India.
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Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair
Arun Gupta,Qin Yang,Raj K. Pandita,Clayton R. Hunt,Tao Xiang,Sandeep Misri,Sicong Zeng,Julia K. Pagan,Jessie Jeffery,Janusz Puc,Rakesh Kumar,Zhihui Feng,Simon N. Powell,Audesh Bhat,Tomoko Yaguchi,Renu Wadhwa,Sunil C. Kaul,Ramon Parsons,Kum Kum Khanna,Tej K. Pandita +19 more
TL;DR: The results indicate that PTEN deficiency alters multiple cell cycle checkpoints possibly leaving less time for DNA damage repair and/or chromosome segregation as evidenced by the increased structural as well as numerical alterations seen in PTEN deficient cells.
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Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells
TL;DR: The observations collectively support a notion that Rev3 is required for the efficient replication of CFSs during G2/M phase, and that the resulting fragile site instability in Rev3 knockout mice may trigger cell death during embryonic development.
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The Indian origin of paternal haplogroup R1a1* substantiates the autochthonous origin of Brahmins and the caste system.
Swarkar Sharma,Ekta Rai,Ekta Rai,Prithviraj Sharma,Mamata Jena,Shweta Singh,Katayoon Darvishi,Audesh Bhat,A.J.S. Bhanwer,Pramod Kumar Tiwari,Rameshwar N. K. Bamezai +10 more
TL;DR: Ongoing observation of the highest frequency of Y-haplogroup R1a1* in Brahmins hinted at its presence as a founder lineage for this caste group, and extended phylogenetic analyses of the pooled dataset supported the autochthonous origin of R 1a1 lineage in India and a tribal link to IndianBrahmins.