S
Susana Gonzalo
Researcher at Saint Louis University
Publications - 60
Citations - 5403
Susana Gonzalo is an academic researcher from Saint Louis University. The author has contributed to research in topics: Lamin & Genome instability. The author has an hindex of 30, co-authored 56 publications receiving 4782 citations. Previous affiliations of Susana Gonzalo include Carlos III Health Institute & Buck Institute for Research on Aging.
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Journal ArticleDOI
DNA methyltransferases control telomere length and telomere recombination in mammalian cells.
TL;DR: A role for mammalian DNA methyltransferases (DNMTs) in telomere length control is described and it is demonstrated that mouse subtelomeric regions are heavily methylated, and that this modification is decreased in DNMT-deficient cells.
Journal ArticleDOI
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases
Roberta Benetti,Susana Gonzalo,Susana Gonzalo,Isabel Jaco,Purificación Muñoz,Susana Gonzalez,Stefan Schoeftner,Elizabeth P. Murchison,Thomas Andl,Taiping Chen,Peter Klatt,En Li,Manuel Serrano,Sarah E. Millar,Gregory J. Hannon,Maria A. Blasco +15 more
TL;DR: A pathway by which miR-290 directly regulates Rbl2-dependent Dnmt expression is identified, indirectly affecting telomere-length homeostasis.
Journal ArticleDOI
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.
Brendan Jones,Hui Su,Audesh Bhat,Hong Lei,Jeffrey Bajko,Sarah Hevi,Gretchen A. Baltus,Shilpa Kadam,Huili Zhai,Reginald Valdez,Susana Gonzalo,Yi Zhang,Yi Zhang,En Li,Taiping Chen +14 more
TL;DR: Results indicate that Dot1L and H3K79 methylation play important roles in heterochromatin formation and in embryonic development.
Journal ArticleDOI
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
Susana Gonzalo,Marta García-Cao,Mario F. Fraga,Gunnar Schotta,Antoine H.F.M. Peters,Shane E. Cotter,Raúl Eguı́a,Douglas C. Dean,Douglas C. Dean,Manel Esteller,Thomas Jenuwein,Maria A. Blasco +11 more
TL;DR: Observations indicate that the RB1 family is involved in maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin, linking tumour suppression and the epigenetic definition of chromatin.
Journal ArticleDOI
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases (Nature Structural and Molecular Biology (2008) 15, (268-279))
Roberta Benetti,Susana Gonzalo,Isabel Jaco,Purificación Mũoz,Susana González,Stefan Schoeftner,Elizabeth P. Murchison,Thomas Andl,Taiping Chen,Peter Klatt,En Li,Manuel Serrano,Sarah E. Millar,Gregory J. Hannon,Maria A. Blasco +14 more
TL;DR: A pathway by which miR-290 directly regulates Rbl2-dependent Dnmt expression is identified, indirectly affecting telomere-length homeostasis.