T
Taiping Chen
Researcher at University of Texas MD Anderson Cancer Center
Publications - 55
Citations - 10269
Taiping Chen is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 38, co-authored 53 publications receiving 9485 citations. Previous affiliations of Taiping Chen include Harvard University & McGill University.
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Journal ArticleDOI
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
Bernhard Lehnertz,Yoshihide Ueda,Alwin A.H.A. Derijck,Ulrich Braunschweig,Laura Perez-Burgos,Stefan Kubicek,Taiping Chen,En Li,Thomas Jenuwein,Antoine H.F.M. Peters +9 more
TL;DR: An evolutionarily conserved pathway between histone H3-K9 methylation and DNA methylation in mammals is demonstrated and both methylation systems are likely to be important in reinforcing the stability of heterochromatic subdomains and thereby in protecting genome integrity.
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The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
Jing Wang,Sarah Hevi,Julia K. Kurash,Hong Lei,Jeffrey Bajko,Hui Su,Weitao Sun,Hua Chang,Guoliang Xu,François Gaudet,En Li,Taiping Chen +11 more
TL;DR: It is suggested that LSD1 demethylates and stabilizes Dnmt1, thus providing a previously unknown mechanistic link between the histone and DNA methylation systems.
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Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.
TL;DR: It is demonstrated that genomic methylation patterns are determined partly through differential expression of different Dnmt3a and DNmt3b isoforms, and that hypermethylation of genomic DNA by Dn MT3b is necessary for ES cells to form teratomas in nude mice.
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Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells
Yufei Xu,Feizhen Wu,Li Tan,Lingchun Kong,Lijun Xiong,Jie Deng,Andrew J. Barbera,Lijuan Zheng,Haikuo Zhang,Stephen A. Huang,Jinrong Min,Thomas B. Nicholson,Taiping Chen,Guoliang Xu,Yang Shi,Yang Shi,Kun Zhang,Yujiang Geno Shi,Yujiang Geno Shi +18 more
TL;DR: The data suggest that Tet1 controls DNA methylation both by binding to CpG-rich regions to prevent unwanted DNA methyltransferase activity, and by converting 5mC to 5hmC through hydroxylase activity.
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DNA methyltransferases control telomere length and telomere recombination in mammalian cells.
TL;DR: A role for mammalian DNA methyltransferases (DNMTs) in telomere length control is described and it is demonstrated that mouse subtelomeric regions are heavily methylated, and that this modification is decreased in DNMT-deficient cells.