A
Augen A. Pioszak
Researcher at University of Oklahoma Health Sciences Center
Publications - 38
Citations - 1733
Augen A. Pioszak is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 20, co-authored 35 publications receiving 1481 citations. Previous affiliations of Augen A. Pioszak include University of Michigan & Van Andel Institute.
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Journal ArticleDOI
Molecular recognition of parathyroid hormone by its G protein-coupled receptor
Augen A. Pioszak,H. Eric Xu +1 more
TL;DR: A method for expression and purification of the extracellular domain (ECD) of human PTH1R engineered as a maltose-binding protein (MBP) fusion that readily crystallizes is presented, revealing critical insights into PTH actions and providing a rational template for drug design that targets this hormone signaling pathway.
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Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.
TL;DR: Three crystal structures of the human CRFR1 ECD are presented, one in a ligand-free form and two in distinct CRF-bound states, providing a molecular framework for understanding peptide binding and specificity by the CRF receptors as a template for designing potent and selective CRFR 1 antagonists for therapeutic applications.
Journal ArticleDOI
Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles
Debbie L. Hay,Augen A. Pioszak +1 more
TL;DR: The first peptide-bound structures of RAMP-GPCR complexes are discussed, which give insight into the molecular mechanisms that enable RAMPs to alter the pharmacology and signaling of GPCRs.
Journal ArticleDOI
Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides
TL;DR: A molecular model is established for better understanding of how two biologically distinct ligands can act through a single receptor and provide a template for designing better PTH/PTHrP therapeutics.
Journal ArticleDOI
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Jason M. Booe,Christopher S. Walker,James Barwell,Gabriel Kuteyi,John Simms,Muhammad A. Jamaluddin,Margaret L. Warner,Roslyn M. Bill,Paul W. R. Harris,Margaret A. Brimble,David R. Poyner,Debbie L. Hay,Augen A. Pioszak +12 more
TL;DR: The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.