P
Paul W. R. Harris
Researcher at University of Auckland
Publications - 26
Citations - 1037
Paul W. R. Harris is an academic researcher from University of Auckland. The author has contributed to research in topics: Peptide synthesis & Native chemical ligation. The author has an hindex of 22, co-authored 26 publications receiving 913 citations. Previous affiliations of Paul W. R. Harris include University of Washington.
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Journal ArticleDOI
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Jason M. Booe,Christopher S. Walker,James Barwell,Gabriel Kuteyi,John Simms,Muhammad A. Jamaluddin,Margaret L. Warner,Roslyn M. Bill,Paul W. R. Harris,Margaret A. Brimble,David R. Poyner,Debbie L. Hay,Augen A. Pioszak +12 more
TL;DR: The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.
Journal ArticleDOI
A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry.
TL;DR: A versatile chemical toolkit for the fully convergent synthesis of neoglycoproteins using click chemistry, native chemical ligation, and kinetically controlled ligation is demonstrated.
Proceedings ArticleDOI
Statistical affect detection in collaborative chat
Michael Brooks,Katie Kuksenok,Megan K. Torkildson,Daniel Perry,John J. Robinson,Taylor Jackson Scott,Ona Anicello,Ariana Zukowski,Paul W. R. Harris,Cecilia Aragon +9 more
TL;DR: A pipeline of natural language processing and machine learning techniques that can be used to build automated classifiers of affect in chat logs are presented and can successfully identify many commonly occurring types of affect.
Journal ArticleDOI
Firn Model Intercomparison Experiment (FirnMICE)
Jessica Lundin,C. Max Stevens,Robert J. Arthern,Christo Buizert,Anais Orsi,Stefan R. M. Ligtenberg,Sebastian B. Simonsen,Evan Cummings,Richard Essery,Will Leahy,Paul W. R. Harris,Michiel M. Helsen,Edwin D. Waddington +12 more
TL;DR: In this paper, the authors quantitatively characterize the differences among the results from the various firn-densification models, and find depth-integrated porosity is unlikely to be inferred with confidence from a firn model to better than 2 m in steady state at a specific site with known accumulation rate and temperature.
Journal ArticleDOI
Direct peptide lipidation through thiol-ene coupling enables rapid synthesis and evaluation of self-adjuvanting vaccine candidates.
Tom H. Wright,Anna E. S. Brooks,Alicia J. Didsbury,Geoffrey M. Williams,Paul W. R. Harris,P. Rod Dunbar,Margaret A. Brimble +6 more
TL;DR: Application of a novel thiol-ene lipidation enables the one-step synthesis of self-adjuvanting antigenic peptides as vaccine candidates and the resultant monoacyl lipopeptides are shown to activate monocytes in a robust manner.