J
John Simms
Researcher at Aston University
Publications - 63
Citations - 2296
John Simms is an academic researcher from Aston University. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 25, co-authored 58 publications receiving 2002 citations. Previous affiliations of John Simms include University College Birmingham & University of Bristol.
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Journal ArticleDOI
Lifting the lid on GPCRs: the role of extracellular loops
Mark Wheatley,Denise Wootten,Matthew T. Conner,John Simms,R Kendrick,Richard T Logan,Poyner,James Barwell +7 more
TL;DR: A review of the key roles of extracellular loops in ligand binding, activation and regulation of both family A and family B GPCRs is presented in this article, with a focus on the role of ECL segments.
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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
TL;DR: The importance of polar transmembrane residues conserved within family B G protein-coupled receptors, not only for protein folding and expression, but also in controlling activation transition, ligand-biased, and pathway-biased signaling is demonstrated.
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Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening
Cassandra Koole,Denise Wootten,John Simms,Celine Valant,Rohan Sridhar,Owen L. Woodman,Laurence J. Miller,Roger J. Summers,Arthur Christopoulos,Patrick M. Sexton +9 more
TL;DR: Investigation of two GLP-1 receptor allosteric modulators and their ability to modify binding and signaling of naturally occurring endogenous peptide agonists highlights the potential for distinct clinical efficacy depending on the properties of individual drugs.
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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism
Denise Wootten,Christopher A. Reynolds,Kevin J. Smith,Juan Carlos Mobarec,Cassandra Koole,Cassandra Koole,Emilia Elizabeth Savage,Kavita Pabreja,John Simms,Rohan Sridhar,Sebastian G.B. Furness,Mengjie Liu,Philip E. Thompson,Laurence J. Miller,Arthur Christopoulos,Patrick M. Sexton +15 more
TL;DR: The data reveal that peptide agonists can engage different elements of the receptor extracellular face to achieve effector coupling and biased signaling providing a foundation for rational design of biased agonists.
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Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Jason M. Booe,Christopher S. Walker,James Barwell,Gabriel Kuteyi,John Simms,Muhammad A. Jamaluddin,Margaret L. Warner,Roslyn M. Bill,Paul W. R. Harris,Margaret A. Brimble,David R. Poyner,Debbie L. Hay,Augen A. Pioszak +12 more
TL;DR: The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.