Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Jason M. Booe,Christopher S. Walker,James Barwell,Gabriel Kuteyi,John Simms,Muhammad A. Jamaluddin,Margaret L. Warner,Roslyn M. Bill,Paul W. R. Harris,Margaret A. Brimble,David R. Poyner,Debbie L. Hay,Augen A. Pioszak +12 more
TLDR
The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.About:
This article is published in Molecular Cell.The article was published on 2015-06-18 and is currently open access. It has received 103 citations till now. The article focuses on the topics: Receptor Activity-Modifying Protein 1 & RAMP2.read more
Citations
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Journal ArticleDOI
The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors.
Stephen P.H. Alexander,Anthony P. Davenport,Eamonn Kelly,Neil V. Marrion,John A. Peters,Helen E. Benson,Elena Faccenda,Adam J. Pawson,Joanna L. Sharman,Christopher Southan,Jamie A. Davies +10 more
TL;DR: The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties.
Journal ArticleDOI
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25
TL;DR: An update on the pharmacology of the calcitonin family of peptides is provided by members of the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology and colleagues.
Journal ArticleDOI
Amylin: Pharmacology, Physiology, and Clinical Potential
TL;DR: Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol and is used clinically to treat type 1 and type 2 diabetes.
Journal ArticleDOI
Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor
Yi Lynn Liang,Maryam Khoshouei,Maryam Khoshouei,Giuseppe Deganutti,Alisa Glukhova,Cassandra Koole,Thomas S. Peat,Mazdak Radjainia,Mazdak Radjainia,Jürgen M. Plitzko,Wolfgang Baumeister,Laurence J. Miller,Laurence J. Miller,Debbie L. Hay,Arthur Christopoulos,Christopher A. Reynolds,Denise Wootten,Denise Wootten,Patrick M. Sexton,Patrick M. Sexton +19 more
TL;DR: Structural insight is provided into the regulation of G-protein-coupled receptors by receptor activity modifying protein 1 and molecular dynamics simulations indicate that RAMP1 provides stability to the receptor complex, particularly in the positioning of the extracellular domain of CLR.
Journal ArticleDOI
Complex Pharmacology of Free Fatty Acid Receptors
TL;DR: The FFA family of receptors is a recently deorphanized set of GPCRs, the members of which are now receiving substantial interest as novel targets for the treatment of metabolic and inflammatory diseases.
References
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