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Aurélien Sokal
Researcher at University of Paris
Publications - 19
Citations - 563
Aurélien Sokal is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 8 publications receiving 98 citations. Previous affiliations of Aurélien Sokal include Paris Descartes University.
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Journal ArticleDOI
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Aurélien Sokal,Pascal Chappert,Giovanna Barba-Spaeth,Anaïs Roeser,Slim Fourati,Imane Azzaoui,Alexis Vandenberghe,Ignacio Fernandez,Annalisa Meola,Magali Bouvier-Alias,Etienne Crickx,Asma Beldi-Ferchiou,Sophie Hue,Laetitia Languille,Marc Michel,Samia Baloul,Marine Luka,Marine Luka,Jérôme Mégret,Mickaël M. Ménager,Mickaël M. Ménager,Jean-Michel Pawlotsky,Simon Fillatreau,Félix A. Rey,Jean-Claude Weill,Claude-Agnès Reynaud,Matthieu Mahévas +26 more
TL;DR: In this paper, a longitudinal single-cell and repertoire profiling of the B cell response up to 6 months in mild and severe COVID-19 patients was performed, showing that an antigen-driven activation persisted and matured up to six months after SARS-CoV-2 infection and may provide longterm protection.
Posted ContentDOI
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Aurélien Sokal,Pascal Chappert,Anaïs Roeser,Giovanna Barba-Spaeth,Slim Fourati,Imane Azzaoui,Alexis Vandenberghe,Ignacio Fernandez,Magali Bouvier-Alias,Etienne Crickx,Asma Beldi Ferchiou,Sophie Hue,Laetitia Languille,Samia Baloul,Marine Luka,Jérôme Mégret,Mickaël M. Ménager,Jean-Michel Pawlotsky,Simon Fillatreau,Félix A. Rey,Jean-Claude Weill,Claude-Agnès Reynaud,Matthieu Mahévas +22 more
TL;DR: It is demonstrated that an antigen-driven activation persisted and matured up to 6 months after SARS-CoV-2 infection and may provide long-term protection.
Journal ArticleDOI
mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.
Aurélien Sokal,Giovanna Barba-Spaeth,Ignacio Fernández,Matteo Broketa,Imane Azzaoui,Andrea De La Selle,Alexis Vandenberghe,Slim Fourati,Anaïs Roeser,Annalisa Meola,Magali Bouvier-Alias,Etienne Crickx,Laetitia Languille,Marc Michel,Bertrand Godeau,S. Gallien,Giovanna Melica,Yann Nguyen,Virginie Zarrouk,Florence Canoui-Poitrine,Jérôme Mégret,Jean-Michel Pawlotsky,Simon Fillatreau,Pierre Bruhns,Félix A. Rey,Jean-Claude Weill,Claude-Agnès Reynaud,Pascal Chappert,Matthieu Mahévas +28 more
TL;DR: This article studied longitudinal cohorts of naive and disease-recovered individuals for up to 2 months after SARS-CoV-2 mRNA vaccination and assessed the quality of the memory response by analysis of antibody repertoires, affinity, and neutralization against variants of concern (VOCs) using unbiased cultures of 2,452 MBCs.
Journal ArticleDOI
Analysis of mRNA vaccination-elicited RBD-specific memory B cells reveals strong but incomplete immune escape of the SARS-CoV-2 Omicron variant
Aurélien Sokal,M M Broketa,Giovanna Barba-Spaeth,Annalisa Meola,Ignacio Fernandez,Slim Fourati,Imane Azzaoui,Andréa de la Selle,Alexis Vandenberghe,Anaïs Roeser,Magali Bouvier-Alias,Etienne Crickx,Laetitia Languille,Marc Michel,Bertrand Godeau,Sebastien Gallien,Giovanna Melica,Yann Nguyen,Virginie Zarrouk,Florence Canoui-Poitrine,F. Noizat-Pirenne,Jérôme Mégret,Jean-Michel Pawlotsky,Simon Fillatreau,Etienne Simon-Loriere,Jean-Claude Weill,Claude-Agnès Reynaud,Félix A. Rey,Pierre Bruhns,Pascal Chappert,Matthieu Mahévas +30 more
TL;DR: In this article , the authors assessed the affinity and neutralization potency against the Omicron variant of several hundred naturally expressed MBC-derived monoclonal IgG antibodies from vaccinated COVID-19-recovered and -naive individuals.
Journal ArticleDOI
Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia.
Etienne Crickx,Etienne Crickx,Pascal Chappert,Aurélien Sokal,Sandra K. Weller,Imane Azzaoui,Alexis Vandenberghe,Guillaume Bonnard,Geoffrey Rossi,Tatiana Fadeev,Sébastien Storck,Jehane Fadlallah,Véronique Meignin,Etienne Rivière,Sylvain Audia,Bertrand Godeau,Marc Michel,Jean-Claude Weill,Claude-Agnès Reynaud,Matthieu Mahévas,Matthieu Mahévas +20 more
TL;DR: In this article, the cellular basis responsible for disease relapse in secondary lymphoid organs in humans was characterized, taking advantage of the opportunity offered by therapeutic splenectomy in patients with relapsing immune thrombocytopenia.