Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration
Steven M. Frank,Bagrat Abazyan,Masahiro Ono,Charles W. Hogue,David B. Cohen,Dan E. Berkowitz,Paul M. Ness,Viachaslau Barodka +7 more
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TLDR
It is demonstrated that increased duration of erythrocyte storage is associated with decreased cell membrane deformability and that these changes are not readily reversible after transfusion.Abstract:
BACKGROUND:Erythrocyte cell membranes undergo morphologic changes during storage, but it is unclear whether these changes are reversible. We assessed erythrocyte cell membrane deformability in patients before and after transfusion to determine the effects of storage duration and whether changes in dread more
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Alternatives to blood transfusion
TL;DR: The current roles of alternatives to blood in the management of medical and surgical anaemias is summarised and the inherent risks of blood, along with the continued rise in blood costs are likely to favour the continued development and use of Alternatives to blood transfusion.
Journal ArticleDOI
Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical Trial
Aggrey Dhabangi,Brenda Ainomugisha,Christine Cserti-Gazdewich,Henry Ddungu,Dorothy Kyeyune,Ezra Musisi,Robert O. Opoka,Christopher P. Stowell,Walter H. Dzik +8 more
TL;DR: Among children with lactic acidosis due to severe anemia, transfusion of longer-storage compared with shorter-storage RBC units did not result in inferior reduction of elevated blood lactate levels, and these findings have relevance regarding the efficacy of stored RBC transfusion for patients with critical tissue hypoxia and lactic acids due to anemia.
Journal ArticleDOI
Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II.
Nisha G. Sosale,Tahereh Rouhiparkouhi,Andrew Bradshaw,Rumiana Dimova,Reinhard Lipowsky,Dennis E. Discher +5 more
TL;DR: It is demonstrated that rigidity of a phagocytosed cell also hyperactivates myosin-II, which locally overwhelms self-signaling at a phAGocytic synapse, and physical properties of phagocytes regulate self signaling, as is relevant to erythropoiesis.
Journal ArticleDOI
Optimization of blood supply chain with shortened shelf lives and ABO compatibility
Qinglin Duan,T. Warren Liao +1 more
TL;DR: The proposed SO framework is incorporated with a new metaheuristic optimization algorithm, TA–TS, to identify near-optimal inventory policies in reasonably acceptable computational time and is shown to offer a better tradeoff between solution accuracy and computational expense.
Journal ArticleDOI
Does prolonged storage of red blood cells cause harm
TL;DR: Institutions involved in blood collection and transfusion should explore strategies that assure blood availability, while limiting the use of the oldest RBCs currently approved by regulation.
References
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Journal ArticleDOI
Blood rheology and hemodynamics.
TL;DR: Blood rheology has been reported to be altered in various physiopathological processes: Alterations of hematocrit significantly contribute to hemorheological variations in diseases and in certain extreme physiological conditions, and RBC deformability is sensitive to local and general homeostasis.
Journal ArticleDOI
Effect of Stored-Blood Transfusion on Oxygen Delivery in Patients With Sepsis
Paul E. Marik,William J. Sibbald +1 more
TL;DR: It is postulate that the poorly deformable transfused red blood cells cause micro-circulatory occlusion in some organs, which may lead to tissue ischemia inSome organs.
Journal ArticleDOI
Clinical consequences of red cell storage in the critically ill
TL;DR: Red cell transfusions are a potentially life‐saving therapy employed during the care of many critically ill patients to replace losses in hemoglobin to maintain oxygen delivery to vital organs and data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs.
Journal ArticleDOI
Effect of Fresh Red Blood Cell Transfusions on Clinical Outcomes in Premature, Very Low-Birth-Weight Infants: The ARIPI Randomized Trial
Dean Fergusson,Paul C. Hébert,Debora L. Hogan,Louise LeBel,Nicole Rouvinez-Bouali,John A. Smyth,Koravangattu Sankaran,Alan Tinmouth,Morris A. Blajchman,Lajos Kovacs,Christian Lachance,Shoo K. Lee,C. Robin Walker,Brian Hutton,Robin Ducharme,Katelyn Balchin,Tim Ramsay,Jason C. Ford,Ashok Kakadekar,K.P. Ramesh,Stan Shapiro +20 more
TL;DR: In this trial, the use of fresh RBCs compared with standard blood bank practice did not improve outcomes in premature, very low-birth-weight infants requiring a transfusion.
Journal ArticleDOI
Influence of storage on red blood cell rheological properties.
Tamara L. Berezina,Sergey B. Zaets,Claire Morgan,Charles R. Spillert,M. Kamiyama,Zoltán Spolarics,Edwin A. Deitch,George W. Machiedo +7 more
TL;DR: Serious hemorrheological disorders, including the decrease in RBC deformability secondary to shape abnormalities, acidosis, and the decrease of blood clotting, start already at the second week of storage and progress up to the end of the storage period.
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