B
Barbara Klink
Researcher at Dresden University of Technology
Publications - 99
Citations - 3820
Barbara Klink is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Glioma & Cancer. The author has an hindex of 27, co-authored 88 publications receiving 2777 citations. Previous affiliations of Barbara Klink include German Cancer Research Center & University of Düsseldorf.
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Journal ArticleDOI
Long-term survival with glioblastoma multiforme
Dietmar Krex,Barbara Klink,Christian Hartmann,Andreas von Deimling,Torsten Pietsch,Matthias Simon,Michael Sabel,Joachim P. Steinbach,Oliver Heese,Guido Reifenberger,Michael Weller,Gabriele Schackert +11 more
TL;DR: The association of glioblastoma long-term survival with prognostically favourable clinical factors, in particular young age and good initial performance score, as well as MGMT promoter hypermethylation is underline.
Journal ArticleDOI
Integrative genomic and transcriptomic analysis of leiomyosarcoma
Priya Chudasama,Sadaf S. Mughal,Mathijs A. Sanders,Mathijs A. Sanders,Daniel Hübschmann,Daniel Hübschmann,Inn Chung,Katharina I. Deeg,Siao Han Wong,Sophie Rabe,Mario Hlevnjak,Marc Zapatka,Aurélie Ernst,Kortine Kleinheinz,Matthias Schlesner,Lina Sieverling,Barbara Klink,Evelin Schröck,Remco Hoogenboezem,Bernd Kasper,Christoph E. Heilig,Gerlinde Egerer,Stephan E. Wolf,Christof von Kalle,Roland Eils,Albrecht Stenzinger,Wilko Weichert,Hanno Glimm,Hanno Glimm,Stefan Gröschel,Hans-Georg Kopp,Georg W. Omlor,Burkhard Lehner,Sebastian Bauer,Simon Schimmack,Alexis Ulrich,Gunhild Mechtersheimer,Karsten Rippe,Benedikt Brors,Barbara Hutter,Marcus Renner,Peter Hohenberger,Claudia Scholl,Stefan Fröhling,Stefan Fröhling +44 more
TL;DR: It is shown that LMS tumors are characterized by substantial mutational heterogeneity, near-universal inactivation of TP53 and RB1, widespread DNA copy number alterations including chromothripsis, and frequent whole-genome duplication, and recurrent alterations in telomere maintenance genes.
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Human gastric cancer modelling using organoids
Therese Seidlitz,Sebastian R. Merker,Alexander Rothe,Falk Zakrzewski,Cläre von Neubeck,Konrad Grützmann,Ulrich Sommer,Christine Schweitzer,Sebastian Schölch,Heike Uhlemann,Anne-Marlene Gaebler,Kristin Werner,Mechthild Krause,Gustavo Baretton,Thilo Welsch,Bon-Kyoung Koo,Daniela E. Aust,Barbara Klink,Jürgen Weitz,Daniel E. Stange +19 more
TL;DR: Human and mouse gastric cancer organoids generated to model the disease and perform drug testing to delineate treatment strategies demonstrate their potential usefulness as living biomarkers for therapy response testing.
Journal ArticleDOI
The biology and mathematical modelling of glioma invasion: a review
Juan Carlos López Alfonso,Katrin Talkenberger,Michael Seifert,Barbara Klink,Andrea Hawkins-Daarud,Kristin R. Swanson,Haralampos Hatzikirou,Andreas Deutsch +7 more
TL;DR: This review starts with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of gliomas invasion.
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NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer
Christoph Heining,Peter Horak,Sebastian Uhrig,Paula L Codo,Barbara Klink,Barbara Hutter,Martina Fröhlich,David Bonekamp,Daniela Richter,Katja Steiger,Roland Penzel,Volker Endris,Karl Roland Ehrenberg,Stephanie Frank,Kortine Kleinheinz,Umut H. Toprak,Matthias Schlesner,Ranadip Mandal,Lothar Schulz,Helmut Lambertz,Sebastian Fetscher,Michael Bitzer,Nisar P. Malek,Marius Horger,Nathalia A. Giese,Oliver Strobel,Thilo Hackert,Christoph Springfeld,Lars Feuerbach,Frank Bergmann,Evelin Schröck,Christof von Kalle,Wilko Weichert,Claudia Scholl,Claudia R. Ball,Albrecht Stenzinger,Benedikt Brors,Stefan Fröhling,Hanno Glimm +38 more
TL;DR: This study uncovers recurrent gene rearrangements such as NRG1 fusions as disease-driving events in KRASwt tumors, thereby providing novel insights into oncogenic signaling and new therapeutic options in this entity.