L
Lina Sieverling
Researcher at German Cancer Research Center
Publications - 9
Citations - 664
Lina Sieverling is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Genome & Telomere. The author has an hindex of 8, co-authored 9 publications receiving 428 citations. Previous affiliations of Lina Sieverling include Heidelberg University.
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Journal ArticleDOI
Integrative genomic and transcriptomic analysis of leiomyosarcoma
Priya Chudasama,Sadaf S. Mughal,Mathijs A. Sanders,Mathijs A. Sanders,Daniel Hübschmann,Daniel Hübschmann,Inn Chung,Katharina I. Deeg,Siao Han Wong,Sophie Rabe,Mario Hlevnjak,Marc Zapatka,Aurélie Ernst,Kortine Kleinheinz,Matthias Schlesner,Lina Sieverling,Barbara Klink,Evelin Schröck,Remco Hoogenboezem,Bernd Kasper,Christoph E. Heilig,Gerlinde Egerer,Stephan E. Wolf,Christof von Kalle,Roland Eils,Albrecht Stenzinger,Wilko Weichert,Hanno Glimm,Hanno Glimm,Stefan Gröschel,Hans-Georg Kopp,Georg W. Omlor,Burkhard Lehner,Sebastian Bauer,Simon Schimmack,Alexis Ulrich,Gunhild Mechtersheimer,Karsten Rippe,Benedikt Brors,Barbara Hutter,Marcus Renner,Peter Hohenberger,Claudia Scholl,Stefan Fröhling,Stefan Fröhling +44 more
TL;DR: It is shown that LMS tumors are characterized by substantial mutational heterogeneity, near-universal inactivation of TP53 and RB1, widespread DNA copy number alterations including chromothripsis, and frequent whole-genome duplication, and recurrent alterations in telomere maintenance genes.
Journal ArticleDOI
Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development
Pawel Durek,Karl Nordström,Gilles Gasparoni,Abdulrahman Salhab,Christopher Kressler,Melanie de Almeida,Kevin Bassler,Thomas Ulas,Florian Schmidt,Jieyi Xiong,Petar Glažar,Filippos Klironomos,Anupam Sinha,Sarah Kinkley,Xinyi Yang,Laura Arrigoni,Azim Dehghani Amirabad,Fatemeh Behjati Ardakani,Lars Feuerbach,Oliver Gorka,Peter Ebert,Fabian Müller,Na Li,Stefan Frischbutter,Stephan Schlickeiser,Carla Cendón,Sebastian Fröhler,Bärbel Felder,Nina Gasparoni,Charles D. Imbusch,Barbara Hutter,Gideon Zipprich,Yvonne Tauchmann,Simon Reinke,Georgi I. Wassilew,Ute Hoffmann,Andreas S. Richter,Lina Sieverling,Hyun-Dong Chang,Uta Syrbe,Ulrich Kalus,Jürgen Eils,Benedikt Brors,Thomas Manke,Jürgen Ruland,Thomas Lengauer,Nikolaus Rajewsky,Wei Chen,Jun Dong,Birgit Sawitzki,Ho-Ryun Chung,Philip Rosenstiel,Marcel H. Schulz,Joachim L. Schultze,Andreas Radbruch,Jörn Walter,Alf Hamann,Julia K. Polansky +57 more
TL;DR: Deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA expression in naive, central-, effector-, and terminally differentiated Tmem cells from blood and bone marrow were generated and candidate master regulators of Tmem cell differentiation were identified.
Journal ArticleDOI
Genomic footprints of activated telomere maintenance mechanisms in cancer.
Lina Sieverling,Lina Sieverling,Chen Hong,Chen Hong,Sandra D Koser,Sandra D Koser,Philip Ginsbach,Kortine Kleinheinz,Kortine Kleinheinz,Barbara Hutter,Delia M. Braun,Delia M. Braun,Isidro Cortes-Ciriano,Isidro Cortes-Ciriano,Ruibin Xi,Rolf Kabbe,Peter J. Park,Roland Eils,Roland Eils,Matthias Schlesner,Benedikt Brors,Karsten Rippe,David T. W. Jones,Lars Feuerbach +23 more
TL;DR: The authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.
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The landscape of chromothripsis across adult cancer types
Natalia Voronina,John Wong,Daniel Hübschmann,Mario Hlevnjak,Sebastian Uhrig,Christoph E. Heilig,Peter Horak,Simon Kreutzfeldt,Andreas Mock,Albrecht Stenzinger,Barbara Hutter,Martina Fröhlich,Benedikt Brors,Arne Jahn,Barbara Klink,Laura Gieldon,Lina Sieverling,Lars Feuerbach,Priya Chudasama,Katja Beck,Matthias Kroiss,Christoph Heining,Lino Möhrmann,Andrea Fischer,Andrea Fischer,Evelin Schröck,Evelin Schröck,Hanno Glimm,Marc Zapatka,Peter Lichter,Stefan Fröhling,Aurélie Ernst +31 more
TL;DR: It is shown that chromothripsis affects a substantial proportion of human cancers, with a prevalence of 49% across all cases, and that 49% of cancers exhibit features of chromothRIpsis.
Journal ArticleDOI
TelomereHunter - In silico estimation of telomere content and composition from cancer genomes
Lars Feuerbach,Lina Sieverling,Lina Sieverling,Katharina I. Deeg,Philip Ginsbach,Barbara Hutter,Ivo Buchhalter,Paul A. Northcott,Sadaf S. Mughal,Sadaf S. Mughal,Priya Chudasama,Hanno Glimm,Hanno Glimm,Claudia Scholl,Peter Lichter,Stefan Fröhling,Stefan M. Pfister,David T.W. Jones,Karsten Rippe,Benedikt Brors +19 more
TL;DR: TelomereHunter provides new functionality for the analysis of the footprints of telomere maintenance mechanisms in cancer genomes, which improves the identification and subclassification of the alternative lengthening of Telomeres phenotype.