B
Bas Kreike
Researcher at Netherlands Cancer Institute
Publications - 36
Citations - 4751
Bas Kreike is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 25, co-authored 36 publications receiving 4435 citations.
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Journal ArticleDOI
Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.
Bas Kreike,Marieke van Kouwenhove,Hugo M. Horlings,Britta Weigelt,Hans Peterse,Harry Bartelink,Marc J. van de Vijver +6 more
TL;DR: Triple-negative tumors are synonymous with basal-like tumors, and can be identified by immunohistochemistry, based on gene-expression profiling, which revealed five distinct subgroups of triple-negative breast cancers.
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Refinement of breast cancer classification by molecular characterization of histological special types.
Britta Weigelt,Hugo M. Horlings,Bas Kreike,Malcolm Hayes,Michael Hauptmann,Lodewyk F. A. Wessels,D. De Jong,M.J. van de Vijver,L.J. van 't Veer,Johannes L. Peterse +9 more
TL;DR: The results imply that the correct classification of breast cancers of special histological type will allow a more accurate prognostication of breast cancer patients and facilitate the identification of optimal therapeutic strategies.
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An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
Ralph R. Weichselbaum,Hemant Ishwaran,Taewon Yoon,Dimitry S.A. Nuyten,Samuel W. Baker,Nikolai N. Khodarev,Andy W. Su,Arif Shaikh,Paul Roach,Bas Kreike,Bernard Roizman,Jonas Bergh,Yudi Pawitan,Marc J. van de Vijver,Andy J. Minn +14 more
TL;DR: By providing information on treatment sensitivity or resistance, the IRDS improves outcome prediction when combined with standard markers, risk groups, or other genomic classifiers.
Journal ArticleDOI
Lung metastasis genes couple breast tumor size and metastatic spread
Andy J. Minn,Gaorav P. Gupta,David Padua,Paula D. Bos,Don X. Nguyen,Dimitry S.A. Nuyten,Bas Kreike,Yi Zhang,Yixin Wang,Hemant Ishwaran,John A. Foekens,Marc J. van de Vijver,Joan Massagué +12 more
TL;DR: The mechanistic linkage between metastasis gene expression, accelerated tumor growth, and likelihood of metastatic recurrence provided by the LMS may help to explain observations of prognostic gene signatures in primary cancer and how tumor growth can both lead to metastasis and be a marker for cells destined to metastasize.
Journal ArticleDOI
Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.
Nicholas C. Turner,M B K Lambros,Hugo M. Horlings,Alex Pearson,Rachel Sharpe,Rachael Natrajan,Felipe C. Geyer,M. van Kouwenhove,Bas Kreike,Alan Mackay,Alan Ashworth,M.J. van de Vijver,Jorge S. Reis-Filho +12 more
TL;DR: It is demonstrated that TNBCs are heterogeneous tumours with amplifications of FGFR2 in a subgroup of tumours.