An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
Ralph R. Weichselbaum,Hemant Ishwaran,Taewon Yoon,Dimitry S.A. Nuyten,Samuel W. Baker,Nikolai N. Khodarev,Andy W. Su,Arif Shaikh,Paul Roach,Bas Kreike,Bernard Roizman,Jonas Bergh,Yudi Pawitan,Marc J. van de Vijver,Andy J. Minn +14 more
TLDR
By providing information on treatment sensitivity or resistance, the IRDS improves outcome prediction when combined with standard markers, risk groups, or other genomic classifiers.Citations
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The JAK-STAT pathway at twenty.
George R. Stark,James E. Darnell +1 more
TL;DR: This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interferons and many other cytokines signal through similar mechanisms, and it now serves as a paradigm showing how information from protein-protein contacts at the cell surface can be conveyed directly to genes in the nucleus.
Journal ArticleDOI
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Antonella Sistigu,Takahiro Yamazaki,Erika Vacchelli,Kariman Chaba,David Enot,Julien Adam,Ilio Vitale,Aicha Goubar,Elisa E. Baracco,Catarina Remédios,Laetitia Fend,Dalil Hannani,Laetitia Aymeric,Yuting Ma,Mireia Niso-Santano,Oliver Kepp,Joachim L. Schultze,Thomas Tüting,Filippo Belardelli,Laura Bracci,Valentina La Sorsa,Giovanna Ziccheddu,Paola Sestili,Francesca Urbani,Mauro Delorenzi,Magali Lacroix-Triki,Virginie Quidville,Rosa Conforti,Jean Philippe Spano,Lajos Pusztai,Vichnou Poirier-Colame,Suzette Delaloge,Frédérique Penault-Llorca,Sylvain Ladoire,Laurent Arnould,Joanna Cyrta,Marie Charlotte Dessoliers,Alexander M.M. Eggermont,Marco Bianchi,Mikael J. Pittet,Camilla Engblom,Christina Pfirschke,Xavier Préville,Gilles Uzé,Robert D. Schreiber,Melvyn T. Chow,Mark J. Smyth,Enrico Proietti,Fabrice Andre,Guido Kroemer,Laurence Zitvogel +50 more
TL;DR: The data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens, and it is surmised that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
Journal ArticleDOI
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.
Joseph L. Benci,Bihui Xu,Yu Qiu,Tony J. Wu,Hannah Dada,Christina Twyman-Saint Victor,Lisa Cucolo,David Lee,Kristen E. Pauken,Alexander C. Huang,Tara C. Gangadhar,Ravi K. Amaravadi,Lynn M. Schuchter,Michael Feldman,Hemant Ishwaran,Robert H. Vonderheide,Amit Maity,E. John Wherry,Andy J. Minn +18 more
TL;DR: It is demonstrated that prolonged interferon signaling orchestrates PDL1-dependent and PDL 1-independent resistance to immune checkpoint blockade (ICB) and to combinations such as radiation plus anti-CTLA4, and biomarkers for interferons-driven resistance associate with clinical progression after anti-PD1 therapy.
Journal ArticleDOI
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion
TL;DR: The current knowledge on the pro- and antitumorigenic effects of IFN-γ as part of the complex immune response to cancer is discussed, highlighting the relevance to identify IFn-γ responsive patients for the improvement of therapies that exploit associated signaling pathways.
Journal ArticleDOI
Radiotherapy and immunotherapy: a beneficial liaison?
TL;DR: Data that provide new mechanistic explanations for the success or failure of radiotherapy are highlighted, and how the combination of immune-modulation and radiation could tip the balance of the host immune response to promote cure is postulated.
References
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Journal ArticleDOI
Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
Journal ArticleDOI
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
O. Abe,R. Abe,K. Enomoto,K. Kikuchi,H. Koyama,H. Masuda,Y. Nomura,K. Sakai,K. Sugimachi,T. Tominaga,J. Uchino,M. Yoshida,J. L. Haybittle,C Davies,V. J. Harvey,T. M. Holdaway,R. G. Kay,B. H. Mason,John F. Forbes,Nicholas Wilcken,M. Gnant,Raimund Jakesz,M. Ploner,H. M. A. Yosef,C. Focan,J. P. Lobelle,U. Peek,G. D. Oates,Janet T. Powell,M. Durand,L. Mauriac,A. Di Leo,Stella Dolci,M.J. Piccart,M. B. Masood,D. Parker,J. J. Price,Pierre Hupperets,Sue Jackson,Joseph Ragaz,Donna L. Berry,Gloria Broadwater,C. Cirrincione,Hyman B. Muss,Larry Norton,Raymond B. Weiss,H. Abu-Zahra,S. M. Portnoj,Michael J. Baum,Jack Cuzick,Joan Houghton,David Riley,N. H. Gordon,H. L. Davis,A. Beatrice,J. Mihura,A. Naja,Y. Lehingue,P. Romestaing,J. B. Dubois,Thierry Delozier,J. Mace-Lesec'h,P. Rambert,O. Andrysek,J. Barkmanova,Julie Owen,P. Meier,A Howell,G. C. Ribeiro,R. Swindell,R Alison,J Boreham,Matthew Clarke,Rory Collins,Sarah C. Darby,P. Elphinstone,Vaughan Evans,Jon Godwin,Richard Gray,C. S. Harwood,C. Hicks,Spencer L. James,Elizabeth MacKinnon,Paul McGale,Theresa McHugh,Graham M. Mead,Richard Peto,Yisong Wang,J. Albano,C. F. de Oliveira,H. Gervasio,J. Gordilho,H Johansen,Henning T. Mouridsen,Rebecca Gelman,J.R. Harris,I. C. Henderson,Charles L. Shapiro,K. W. Andersen,C. K. Axelsson,M. Blichert-Toft,S. Moller,Jens Overgaard,Marie Overgaard,Carsten Rose,B. Cartensen,T. Palshof,H. J. Trampisch,Otilia Dalesio,E.G.E. de Vries,Sjoerd Rodenhuis,H. van Tinteren,R. L. Comis,Nancy E. Davidson,Nicholas J. Robert,George W. Sledge,Douglass C. Tormey,William C. Wood,David Cameron,Udi Chetty,P. Forrest,W. Jack,J. Rossbach,Jan G. M. Klijn,A. D. Treurniet-Donker,W. L. J. van Putten,Alberto Costa,Umberto Veronesi,H. Bartelink,L. Duchateau,C. Legrand,RJ Sylvester,J.A. van der Hage,C.J.H. van de Velde,M. P. Cunningham,R. Catalano,R. H. Creech,Jacques Bonneterre,P. Fargeot,Pierre Fumoleau,Pierre Kerbrat,Moïse Namer,Walter Jonat,Manfred Kaufmann,Martin Schumacher,G. von Minckwitz,G. Bastert,H. Rauschecker,R. Sauer,Willi Sauerbrei,A.J. Schauer,A. de Schryver,L. Vakaet,M. Belfiglio,A. Nicolucci,F. Pellegrini,M. Sacco,M. Valentini,C. S. McArdle,D. C. Smith,E. Galligioni,Francesco Boccardo,AU Rubagotti,D. M. Dent,C. A. Gudgeon,A. Hacking,A. Erazo,J. Y. Medina,M. Izuo,Y. Morishita,H. Takei,I.S. Fentiman,John L. Hayward,R D Rubens,D. Skilton,H. Graeff,Fritz Jänicke,C. Meisner,H. R. Scheurlen,D. von Fournier,Urania Dafni,G. Fountzilas,P. Klefstrom,Carl Blomqvist,T. Saarto,R. Margreiter,Bernard Asselain,R. J. Salmon,J. R. Vilcoq,Rodrigo Arriagada,Christopher Hill,A. Laplanche,M. G. Le,M. Spielmann,Paolo Bruzzi,E. Montanaro,R. Rosso,M. R. Sertoli,M. Venturini,Dino Amadori,J. Benraadt,M. Kooi,A. O. van de Velde,J. A. van Dongen,J. B. Vermorken,Monica Castiglione,F. Cavalli,A. S. Coates,J. Collins,JF Forbes,Richard D. Gelber,A. Goldhirsch,J. Lindtner,Karen N. Price,C. M. Rudenstam,H.-J. Senn,Judith M Bliss,Clair Chilvers,R. C. Coombes,Emma Hall,Michel Marty,R. V. Borovik,G. Brufman,H. Hayat,E. Robinson,N. Wigler,Gianni Bonadonna,T. Camerini,G. De Palo,M. Del Vecchio,F. Formelli,Pinuccia Valagussa,A Martoni,F. Pannuti,G. Cocconi,A. Colozza,R. Camisa,K. Aogi,S. Takashima,T. Ikeda,K. Inokuchi,K. Sawa,H. Sonoo,S. Korzeniowski,J. Skolyszewski,M. Ogawa,J. Yamashita,J. Bonte,R. Christiaens,Robert Paridaens,W. Van den Boegart,P. Martin,S. Romain,T. Hakes,Clifford A. Hudis,R. Wittes,G. Giokas,D. Kondylis,B. Lissaios,R. de la Huerta,M. G. Sainz,R. Altemus,K. Cowan,David N. Danforth,Allen S. Lichter,Marc E. Lippman,Joyce A. O'Shaughnessy,Lori J. Pierce,Seth M. Steinberg,D. Venzon,JoAnne Zujewski,A. Paradiso,M. De Lena,F. Schittulli,J. Myles,J. L. Pater,Kathleen I. Pritchard,Stewart J. Anderson,G. Bass,Anna Brown,John Bryant,J. Costantino,James J. Dignam,Bernard Fisher,C Redmond,Sam Wieand,Norman Wolmark,I. M. Jackson,Mike K. Palmer,JN Ingle,Vera J. Suman,Nils-Olof Bengtsson,H. Jonsson,Lars-Gunnar Larsson,J. P. Lythgoe,M. Kissin,Bjørn Erikstein,E Hannisdal,A. B. Jacobsen,J. E. Varhaug,S. Gundersen,Martin Hauer-Jensen,H. Host,R. Nissen-Meyer,Roger W. Blamey,A. Mitchell,Morgan Da,J.F.R. Robertson,M. Di Palma,G. Mathe,J. L. Misset,R. M. Clark,Mitch Levine,K Morimoto,Y. Takatsuka,E. Crossley,Al Harris,Denis Talbot,Mark Taylor,B. di Blasio,V. Ivanov,Vladimir Semiglazov,J. Brockschmidt,M. R. Cooper,H. Ueo,Carla I. Falkson,Roger A'Hern,Stanley W. Ashley,T. J. Powles,Ian E. Smith,John Yarnold,J.-C. Gazet,N. Cocoran,N. Deshpande,L. di Martino,P. Douglas,A. Lindtner,G Notter,A. J. S. Bryant,G. H. Ewing,L. A. Firth,J. L. Krushen-Kosloski,L. Foster,W.D. George,Helen J. Stewart,P. Stroner,Per-Uno Malmström,Torgil Möller,Stefan Rydén,Ingrid Tengrup,Lena Tennvall-Nittby,J. Carstenssen,M. Dufmats,Thomas Hatschek,Bo Nordenskjöld,Martin Söderberg,John T. Carpenter,KS Albain,J. Crowley,Stuart A. Green,Silvana Martino,CK Osborne,Peter M. Ravdin,U. Glas,Ulla Johansson,L E Rutqvist,T. Singnomklao,Arne Wallgren,Rudolf Maibach,Beat Thürlimann,Hermann Brenner,A. Hercbergs,M Yoshimoto,Gerrit DeBoer,Alexander H.G. Paterson,JW Meakin,T. Panzarella,Y. Shan,Y. F. Shao,X. Wang,D. B. Zhao,Z. M. Chen,H. C. Pan,J. Bahi,M. Reid,M. Spittle,G. P. Deutsch,F. Senanayake,D. L. W. Kwong,Angelo Raffaele Bianco,Chiara Carlomagno,M. De Laurentiis,S. De Placido,Aman U. Buzdar,Tae C Smith,Jonas Bergh,Lars Holmberg,Göran Liljegren,Jan Nilsson,M. Seifert,P. Sevelda,C. C. Zielinsky,R. B. Buchanan,M. Cross,G.T. Royle,Janet A. Dunn,Robert Kerrin Hills,Michael Lee,J. M. Morrison,D. Spooner,A. Litton,Rowan T. Chlebowski,H. Caffier +412 more
TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
Journal ArticleDOI
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
Marc J. van de Vijver,Yudong D. He,Laura J. van't Veer,Hongyue Dai,Augustinus A. M. Hart,D.W. Voskuil,George J. Schreiber,Johannes L. Peterse,Christopher J. Roberts,Matthew J. Marton,Mark Parrish,Douwe Atsma,Anke T. Witteveen,Annuska M. Glas,Leonie J. M. J. Delahaye,Tony van de Velde,Harry Bartelink,Sjoerd Rodenhuis,Emiel J. Th. Rutgers,Stephen H. Friend,René Bernards +20 more
TL;DR: The gene-expression profile studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and histologic criteria.
Journal ArticleDOI
Repeated observation of breast tumor subtypes in independent gene expression data sets
Therese Sørlie,Robert Tibshirani,Joel S. Parker,Trevor Hastie,James Stephen Marron,Andrew B. Nobel,Shibing Deng,Hilde Johnsen,Robert Pesich,Stephanie Geisler,Janos Demeter,Charles M. Perou,Per Eystein Lønning,Patrick O. Brown,Anne Lise Børresen-Dale,David Botstein +15 more
TL;DR: The results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities.
Journal ArticleDOI
TM4: a free, open-source system for microarray data management and analysis.
Alexander I. Saeed,Vasily Sharov,James R. White,J. Li,Wei Liang,Nirmal Bhagabati,John C. Braisted,Maria I. Klapa,T. Currier,Mathangi Thiagarajan,Alexander Sturn,Mark Snuffin,A. Rezantsev,D. Popov,A. Ryltsov,E. Kostukovich,I. Borisovsky,Z. Liu,A. Vinsavich,V. Trush,John Quackenbush +20 more
TL;DR: This research presents a novel and scalable approach to genome engineering that addresses the challenge of integrating RNAseq data to provide real-time information about the “silent” response of the immune system to DNA editing.
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Antonella Sistigu,Takahiro Yamazaki,Erika Vacchelli,Kariman Chaba,David Enot,Julien Adam,Ilio Vitale,Aicha Goubar,Elisa E. Baracco,Catarina Remédios,Laetitia Fend,Dalil Hannani,Laetitia Aymeric,Yuting Ma,Mireia Niso-Santano,Oliver Kepp,Joachim L. Schultze,Thomas Tüting,Filippo Belardelli,Laura Bracci,Valentina La Sorsa,Giovanna Ziccheddu,Paola Sestili,Francesca Urbani,Mauro Delorenzi,Magali Lacroix-Triki,Virginie Quidville,Rosa Conforti,Jean Philippe Spano,Lajos Pusztai,Vichnou Poirier-Colame,Suzette Delaloge,Frédérique Penault-Llorca,Sylvain Ladoire,Laurent Arnould,Joanna Cyrta,Marie Charlotte Dessoliers,Alexander M.M. Eggermont,Marco Bianchi,Mikael J. Pittet,Camilla Engblom,Christina Pfirschke,Xavier Préville,Gilles Uzé,Robert D. Schreiber,Melvyn T. Chow,Mark J. Smyth,Enrico Proietti,Fabrice Andre,Guido Kroemer,Laurence Zitvogel +50 more