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Bei Jiang
Researcher at City of Hope National Medical Center
Publications - 6
Citations - 571
Bei Jiang is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 4, co-authored 6 publications receiving 459 citations. Previous affiliations of Bei Jiang include University of Nebraska Medical Center.
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Journal ArticleDOI
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Can Küçük,Bei Jiang,Xiaozhou Hu,Wenyan Zhang,John K.C. Chan,Wenming Xiao,Nathan A. Lack,Can Alkan,John C. Williams,Kendra N. Avery,Painar Kavak,Anna Scuto,Emel Sen,Philippe Gaulard,Lou Staudt,Javeed Iqbal,Weiwei Zhang,Adam Cornish,Qiang Gong,Qun-Pei Yang,Hong Sun,Francesco d'Amore,Sirpa Leppä,Weiping Liu,Kai Fu,Laurence de Leval,Timothy W. McKeithan,Wing C. Chan +27 more
TL;DR: The findings suggest that JAK-STAT pathway inhibition may represent a therapeutic strategy in NK/T-cell lymphomas and their cell lines through next generation and/or Sanger sequencing.
Journal ArticleDOI
IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma
Chao Wang,Chao Wang,Chao Wang,Timothy W. McKeithan,Qiang Gong,Weiwei Zhang,Alyssa Bouska,Andreas Rosenwald,Randy D. Gascoyne,Xiwei Wu,Jinhui Wang,Zahid Muhammad,Bei Jiang,Bei Jiang,Joseph Rohr,Joseph Rohr,Andrew Cannon,Christian Steidl,Kai Fu,Yuping Li,Stacy Hung,Dennis D. Weisenburger,Timothy C. Greiner,Lynette M. Smith,German Ott,Eleanor G. Rogan,Louis M. Staudt,Julie M. Vose,Javeed Iqbal,Wing C. Chan +29 more
TL;DR: Target resequencing on 92 cases of PTCL and frequent mutations affecting RHOA, TET2, DNMT3A, and isocitrate dehydrogenase 2 (IDH2) revealed recurrently hypermethylated genes involved in T-cell receptor signaling and T- cell differentiation that likely contribute to lymphomagenesis in AITL.
Journal ArticleDOI
Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma
Can Küçük,Xiaozhou Hu,Xiaozhou Hu,Bei Jiang,David Klinkebiel,Huimin Geng,Qiang Gong,Alyssa Bouska,Javeed Iqbal,Philippe Gaulard,Timothy W. McKeithan,Wing C. Chan +11 more
TL;DR: Promoter region hypermethylation is frequent in NKCL, and aberrantly methylated genes are pathologically and clinically significant.
Journal ArticleDOI
Diagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Killer/T-Cell Lymphoma
Can Küçük,Can Küçük,Xiaozhou Hu,Qiang Gong,Bei Jiang,Adam Cornish,Philippe Gaulard,Timothy W. McKeithan,Wing C. Chan +8 more
TL;DR: The expression of all KIRs tended to be markedly reduced or absent in NKTCL, except for the KIR family member killer Ig-like receptor 2DL4 (KIR2DL4; alias CD158D), which was selectively overexpressed in the majority (59%) of cases and no specific expression pattern was observed for C-type lectin receptors.
Journal ArticleDOI
Generation of Natural Killer Cell Lymphoma Models In Vitro by Gene Editing
Gehong Dong,Gehong Dong,Yuping Li,Bei Jiang,Jiing-Kuan Yee,Dean A. Lee,Dean A. Lee,Dean A. Lee,Timothy W. McKeithan,Wing C. Chan +9 more
TL;DR: The experience using the CRISPR/Cas9 technology for targeted gene modifications of normal NK-cells in vitro to generate human model systems to study NKCL initiation and progression is reported.