Q
Qiang Gong
Researcher at City of Hope National Medical Center
Publications - 73
Citations - 2326
Qiang Gong is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 20, co-authored 55 publications receiving 1863 citations. Previous affiliations of Qiang Gong include Tsinghua University & Beijing Institute of Genomics.
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Journal ArticleDOI
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
Shaoping Ling,Zheng Hu,Z.F. Yang,Fang Yang,Yawei Li,Pei Lin,Ke Chen,Lili Dong,Lihua Cao,Yong Tao,Lingtong Hao,Qingjian Chen,Qiang Gong,Dafei Wu,Wenjie Li,Wenming Zhao,Xiuyun Tian,Chunyi Hao,Eric A. Hungate,Daniel V.T. Catenacci,Richard R. Hudson,Wen-Hsiung Li,Xuemei Lu,Chung-I Wu,Chung-I Wu,Chung-I Wu +25 more
TL;DR: A single tumor is evaluated by sequencing or genotyping nearly 300 regions from the tumor and the number of coding region mutations was estimated to be greater than 100 million in this unexceptional tumor, suggesting non-Darwinian evolution should be heeded in cancer treatments even for microscopic tumors.
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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Can Küçük,Bei Jiang,Xiaozhou Hu,Wenyan Zhang,John K.C. Chan,Wenming Xiao,Nathan A. Lack,Can Alkan,John C. Williams,Kendra N. Avery,Painar Kavak,Anna Scuto,Emel Sen,Philippe Gaulard,Lou Staudt,Javeed Iqbal,Weiwei Zhang,Adam Cornish,Qiang Gong,Qun-Pei Yang,Hong Sun,Francesco d'Amore,Sirpa Leppä,Weiping Liu,Kai Fu,Laurence de Leval,Timothy W. McKeithan,Wing C. Chan +27 more
TL;DR: The findings suggest that JAK-STAT pathway inhibition may represent a therapeutic strategy in NK/T-cell lymphomas and their cell lines through next generation and/or Sanger sequencing.
Journal ArticleDOI
IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma
Chao Wang,Chao Wang,Chao Wang,Timothy W. McKeithan,Qiang Gong,Weiwei Zhang,Alyssa Bouska,Andreas Rosenwald,Randy D. Gascoyne,Xiwei Wu,Jinhui Wang,Zahid Muhammad,Bei Jiang,Bei Jiang,Joseph Rohr,Joseph Rohr,Andrew Cannon,Christian Steidl,Kai Fu,Yuping Li,Stacy Hung,Dennis D. Weisenburger,Timothy C. Greiner,Lynette M. Smith,German Ott,Eleanor G. Rogan,Louis M. Staudt,Julie M. Vose,Javeed Iqbal,Wing C. Chan +29 more
TL;DR: Target resequencing on 92 cases of PTCL and frequent mutations affecting RHOA, TET2, DNMT3A, and isocitrate dehydrogenase 2 (IDH2) revealed recurrently hypermethylated genes involved in T-cell receptor signaling and T- cell differentiation that likely contribute to lymphomagenesis in AITL.
Journal ArticleDOI
Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma
Tayla Heavican,Alyssa Bouska,Jiayu Yu,Waseem Gul Lone,Catalina Amador,Qiang Gong,Weiwei Zhang,Yuping Li,Bhavana J. Dave,Maarja-Liisa Nairismagi,Timothy Greiner,Julie M. Vose,Dennis D. Weisenburger,Cynthia M. Lachel,Chao Wang,Chao Wang,Kai Fu,Jadd M. Stevens,Soon Thye Lim,Choon Kiat Ong,Randy D. Gascoyne,Edoardo Missiaglia,François Lemonnier,Corinne Haioun,Sylvia Hartmann,Martin Bjerregård Pedersen,Maria Antonella Laginestra,Ryan A. Wilcox,Bin Tean Teh,Noriaki Yoshida,Koichi Ohshima,Masao Seto,Andreas Rosenwald,German Ott,Elias Campo,Lisa M. Rimsza,Elaine S. Jaffe,Rita M. Braziel,Francesco d'Amore,Giorgio Inghirami,Francesco Bertoni,Laurence de Leval,Philippe Gaulard,Louis M. Staudt,Timothy W. McKeithan,Stefano Pileri,Wing C. Chan,Javeed Iqbal +47 more
TL;DR: It is demonstrated that novel GEP-defined PTCL subgroups likely evolve by distinct genetic pathways and provided biological rationale for therapies that may be investigated in future clinical trials.
Journal ArticleDOI
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data
Yong Tao,Jue Ruan,Shiou-Hwei Yeh,Xuemei Lu,Yu Wang,Weiwei Zhai,Jun Cai,Shaoping Ling,Qiang Gong,Zecheng Chong,Zhengzhong Qu,Qianqian Li,Jiang Liu,Jin Yang,Caihong Zheng,Changqing Zeng,Hurng-Yi Wang,Jing Zhang,Sheng-Han Wang,Lingtong Hao,Lili Dong,Wenjie Li,Min Sun,Wei Zou,Caixia Yu,Chaohua Li,Guojing Liu,Lan Jiang,Jin Xu,Huanwei Huang,Chunyan Li,Shuangli Mi,Bing Zhang,Baoxian Chen,Wenming Zhao,Songnian Hu,Shi-Mei Zhuang,Yang Shen,Suhua Shi,Christopher D. Brown,Kevin P. White,Ding-Shinn Chen,Pei-Jer Chen,Chung-I Wu,Chung-I Wu +44 more
TL;DR: By using a cell-population genetic definition, this approach identified three coding changes (CCNG1, P62, and an indel/fusion gene) as tumor driver mutations, functionally distinct from mutations that accumulated earlier, many of which are involved in inflammation/immunity or cell anchoring.