Ben-Zion Garty

TL;DR: In this article, the authors investigated the role of IL-12Rbeta1-dependent signals in the development of human IL-17-producing T helper cells in vivo by quantifying the production and secretion of human interleukin (IL) 17 by fresh T cells ex vivo, and by T cell blasts expanded in vitro from patients with particular genetic traits affecting transforming growth factor (TGF) beta, IL-1, IL 6, or IL-23 responses.

TL;DR: A nationwide multicenter study was performed to investigate the epidemiologic, clinical, and laboratory features of children with culture-proven K. kingae infections, mainly causing skeletal system infections and bacteremia, and occasionally endocarditis and pneumonia.

TL;DR: Nonsense mutations in ZNF341 account for the STAT3-like phenotype in four autosomal-recessive kindreds and reveal a previously unappreciated layer of transcriptional regulation controlling JAK-STAT signaling, a previously unrecognized regulator of immune homeostasis.

TL;DR: It is indicated that invasive K kingae infections occur in previously healthy children, mostly during the first 2 years of life; affected older children usually have an underlying medical condition.

TL;DR: The killer immunoglobulin-like receptor (KIR) family recognizes class I major histocompatibility complex (MHC) molecules and inhibits natural killer activity.