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Benita S. Katzenellenbogen
Researcher at University of Illinois at Urbana–Champaign
Publications - 403
Citations - 41240
Benita S. Katzenellenbogen is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 113, co-authored 394 publications receiving 39585 citations. Previous affiliations of Benita S. Katzenellenbogen include Dartmouth College & University of Cincinnati.
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Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.
Stavroula Kousteni,Teresita Bellido,Lilian I. Plotkin,Charles A. O'Brien,Donald L. Bodenner,Li Han,K. Han,G. B. DiGregorio,John A. Katzenellenbogen,Benita S. Katzenellenbogen,Paula K. Roberson,Robert S. Weinstein,Robert L. Jilka,Stavros C. Manolagas +13 more
TL;DR: A novel paradigm of sex steroid action on osteoblasts, osteocytes, embryonic fibroblasts, and HeLa cells involving activation of a Src/Shc/ERK signaling pathway and attenuating apoptosis is demonstrated, providing proof of principle for the development of function-specific-as opposed to tissue-selective-and gender-neutral pharmacotherapeutics.
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Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture
TL;DR: Phenol red has been found to have significant estrogenic activity at the concentrations (15-45 microM) at which it is found in tissue culture media as mentioned in this paper, which has been shown to stimulate the proliferation of estrogen receptor-positive MCF-7 breast cancer cells in a dose-dependent manner.
Phenol red in tissue culture media is a weak estrogen: Implications concerning the study of estrogen-responsive cells in culture (cell proliferation/human breast cancer/antiestrogens/hormone responsiveness/estrogen receptor)
TL;DR: It is found that phenol red, which bears a structural resemblance to some nonsteroidal estrogens and which is used ubiquitously as a pH indicator in tissue culture media, has significant estrogenic activity at the concentrations (15-45 microM) at which it is found in tissueculture media.
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Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype.
Jonna Frasor,Jeanne M. Danes,Barry S. Komm,Ken C. N. Chang,C. Richard Lyttle,Benita S. Katzenellenbogen +5 more
TL;DR: The use of global gene expression profiling by Affymetrix GeneChip microarray analysis to identify patterns and time courses of genes that are either stimulated or inhibited by estradiol (E2) in estrogen receptor (ER)-positive MCF-7 human breast cancer cells is highlighted.
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Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists
Shaun R. Stauffer,Christopher J Coletta,Rosanna Tedesco,Gisele Nishiguchi,Kathryn E. Carlson,Jun Sun,Benita S. Katzenellenbogen,John A. Katzenellenbogen +7 more
TL;DR: Investigations suggest that the pyrazole triols prefer to bind to ERalpha with their C(3)-phenol in the estradiol A-ring binding pocket and that binding selectivity results from differences in the interaction of thePyrazole core and C(4)-propyl group with portions of the receptor where ERalpha has a smaller residue than ERbeta.