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William J. Calhoun
Researcher at University of Texas Medical Branch
Publications - 107
Citations - 8540
William J. Calhoun is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Asthma & Exhaled nitric oxide. The author has an hindex of 37, co-authored 102 publications receiving 7459 citations. Previous affiliations of William J. Calhoun include University of Texas at Austin.
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Journal ArticleDOI
Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
Wendy C. Moore,Deborah A. Meyers,Sally E. Wenzel,W. Gerald Teague,Huashi Li,Xingnan Li,Ralph B. D'Agostino,Mario Castro,Douglas Curran-Everett,Anne M. Fitzpatrick,Benjamin Gaston,Nizar N. Jarjour,Ronald L. Sorkness,William J. Calhoun,Kian Fan Chung,Suzy A.A. Comhair,Raed A. Dweik,Elliot Israel,Stephen P. Peters,William W. Busse,Serpil C. Erzurum,Eugene R. Bleecker +21 more
TL;DR: Five distinct clinical phenotypes of asthma have been identified using an unsupervised hierarchical cluster analysis, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma.
Journal ArticleDOI
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Dara G. Torgerson,Dara G. Torgerson,Elizabeth J. Ampleford,Grace Y. Chiu,W. James Gauderman,Christopher R. Gignoux,Penelope E. Graves,Blanca E. Himes,Albert M. Levin,Rasika A. Mathias,Dana B. Hancock,Dana B. Hancock,Dana B. Hancock,James W. Baurley,Celeste Eng,Debra A. Stern,Juan C. Celedón,Nicholas Rafaels,Daniel Capurso,David V. Conti,Lindsey A. Roth,Manuel Soto-Quiros,Alkis Togias,Xingnan Li,Rachel A. Myers,Isabelle Romieu,Isabelle Romieu,David Van Den Berg,Donglei Hu,Nadia N. Hansel,Ryan D. Hernandez,Elliott Israel,Muhammad T. Salam,Joshua Galanter,Pedro C. Avila,Lydiana Avila,Jose R. Rodriquez-Santana,R. Chapela,William Rodríguez-Cintrón,Gregory B. Diette,N. Franklin Adkinson,Rebekah A. Abel,K. Ross,Min Shi,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Vito J. Mantese,Serpil C. Ezurum,Liming Liang,Ingo Ruczinski,Jean G. Ford,Scott Huntsman,Kian Fan Chung,Hita Vora,Xia Li,William J. Calhoun,Mario Castro,Juan José Luis Sienra-Monge,Blanca Estela Del Río-Navarro,Klaus A. Deichmann,Andrea Heinzmann,Sally E. Wenzel,William W. Busse,William W. Busse,James E. Gern,Robert F. Lemanske,Terri H. Beaty,Eugene R. Bleecker,Benjamin A. Raby,Deborah A. Meyers,Stephanie J. London,Frank D. Gilliland,Esteban G. Burchard,Fernando D. Martinez,Scott T. Weiss,L. Keoki Williams,Kathleen C. Barnes,Carole Ober,Dan L. Nicolae +79 more
TL;DR: The results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
Journal ArticleDOI
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma.
Yvonne J. Huang,Craig E. Nelson,Eoin L. Brodie,Todd Z. DeSantis,Marshall S. Baek,Jane Liu,Tanja Woyke,Martin Allgaier,James Bristow,Jeanine P. Wiener-Kronish,E. Rand Sutherland,Tonya S. King,Nikolina Icitovic,Richard J. Martin,William J. Calhoun,Mario Castro,Loren C. Denlinger,Emily DiMango,Monica Kraft,Stephen P. Peters,Stephen I. Wasserman,Michael E. Wechsler,Homer A. Boushey,Susan V. Lynch +23 more
TL;DR: The composition of Bronchial airway microbiota is associated with the degree of bronchial hyperresponsiveness among patients with suboptimally controlled asthma, and these findings support the need for further functional studies to examine the potential contribution of members of theAirway microbiota in asthma pathogenesis.
Journal ArticleDOI
Tiotropium bromide step-up therapy for adults with uncontrolled asthma
Stephen P. Peters,Susan J. Kunselman,Nikolina Icitovic,Wendy C. Moore,Rodolfo M. Pascual,Bill T. Ameredes,Homer A. Boushey,William J. Calhoun,Mario Castro,Reuben M. Cherniack,Timothy J. Craig,Loren C. Denlinger,Linda Engle,Emily DiMango,John V. Fahy,Elliot Israel,Nizar N. Jarjour,Shamsah Kazani,Monica Kraft,Stephen C. Lazarus,Robert F. Lemanske,Njira L Lugogo,Richard J. Martin,Deborah A. Meyers,Joe W. Ramsdell,Christine A. Sorkness,E. Rand Sutherland,Stanley J. Szefler,Stephen I. Wasserman,Michael J. Walter,Michael E. Wechsler,Vernon M. Chinchilli,Eugene R. Bleecker +32 more
TL;DR: When added to an inhaled glucocorticoid, tiotropium improved symptoms and lung function in patients with inadequately controlled asthma and its effects appeared to be equivalent to those with the addition of salmeterol.
Journal ArticleDOI
Obesity and asthma, an association modified by age of asthma onset
Fernando Holguin,Eugene R. Bleecker,William W. Busse,William J. Calhoun,Mario Castro,Serpil C. Erzurum,Anne M. Fitzpatrick,Benjamin Gaston,Elliot Israel,Nizar N. Jarjour,Wendy C. Moore,Stephen P. Peters,Michael A. Yonas,W. Gerald Teague,Sally E. Wenzel +14 more
TL;DR: Asthmatic subjects are differentially affected by obesity based on whether they had asthma early (<12 years of age) or later in life, and this results highlight the need to understand obesity as a comorbidity that affects specific clinical phenotypes and not all asthma subjects alike.