Journal ArticleDOI
The when and wheres of CDC25 phosphatases.
Reads0
Chats0
TLDR
Recent data demonstrate that in addition to the ATM/ATR-CHK pathway, a p38-MAPKAP pathway is also involved in controlling CDC25 activity during G(2)/M checkpoint activation and highlight the significance of developing specific CDC25 inhibitors for cancer therapy.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2006-04-01. It has received 421 citations till now. The article focuses on the topics: Cdc25 & CDC25A.read more
Citations
More filters
Journal ArticleDOI
ATR: an essential regulator of genome integrity
Karlene A. Cimprich,David Cortez +1 more
TL;DR: New insights are provided into the mechanisms that control ATR activation, which have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of AtR in maintaining genome integrity.
Journal ArticleDOI
CDC25 phosphatases in cancer cells: key players? Good targets?
TL;DR: The roles of CDC25 phosphatases in both normal and abnormal cell proliferation are focused on, a critical assessment of the current data on CDC25 overexpression in cancer is provided, and both current and future therapeutic strategies for targeting CDC25 activity in cancer treatment are discussed.
Journal ArticleDOI
The decision to enter mitosis: feedback and redundancy in the mitotic entry network.
TL;DR: The role of various feedback loops that regulate cyclin B–Cdk1 activation under different conditions, the timing of their activation, and the possible identity of the elusive trigger that controls mitotic entry in human cells are discussed.
Journal ArticleDOI
The essential kinase ATR: ensuring faithful duplication of a challenging genome
TL;DR: This Review examines how the replication stress response that is controlled by the kinase ataxia telangiectasia and Rad3-related (ATR) senses and resolves threats to DNA integrity so that the DNA remains available to read in all of the authors' cells.
Journal ArticleDOI
The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites
Gerard E. Kaiko,Stacy H. Ryu,Olivia I. Koues,Patrick L. Collins,Lilianna Solnica-Krezel,Edward J. Pearce,Erika L. Pearce,Eugene M. Oltz,Thaddeus S. Stappenbeck +8 more
TL;DR: It is indicated that mammalian crypt architecture protects stem/progenitor cell proliferation in part through a metabolic barrier formed by differentiated colonocytes that consume butyrate and stimulate future studies on the interplay of host anatomy and microbiome metabolism.
References
More filters
Journal ArticleDOI
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.
TL;DR: Results indicate that serine-216 phosphorylation and 14-3-3 binding negatively regulate Cdc25C and identify CDC25C as a potential target of checkpoint control in human cells.
Journal ArticleDOI
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
TL;DR: Chk2, the mammalian homolog of the Saccharomyces cerevisiae Rad53 and Schizosac charomyces pombe Cds1 protein kinases required for the DNA damage and replication checkpoints, was identified and phosphorylated and activated in response to replication blocks and DNA damage.
Journal ArticleDOI
Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
Yolanda Sanchez,Calvin Wong,Calvin Wong,Richard S. Thoma,Richard S. Thoma,Ron Richman,Ron Richman,Zhiqi Wu,Zhiqi Wu,Helen Piwnica-Worms,Stephen J. Elledge,Stephen J. Elledge +11 more
TL;DR: Results suggest a model whereby in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry.
Journal ArticleDOI
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
TL;DR: A functional link between ATM, the checkpoint signalling kinase Chk2/Cds1 (Chk2) and Cdc25A is reported, and this mechanism in controlling the S-phase checkpoint is identified as a genomic integrity checkpoint that prevents radioresistant DNA synthesis.
Journal ArticleDOI
cdc25+ functions as an inducer in the mitotic control of fission yeast.
Paul Russell,Paul Nurse +1 more
TL;DR: Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic inhibitor wee1+, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.