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Berta N. Vazquez
Researcher at Rutgers University
Publications - 19
Citations - 976
Berta N. Vazquez is an academic researcher from Rutgers University. The author has contributed to research in topics: Chromatin & Sirtuin. The author has an hindex of 12, co-authored 18 publications receiving 762 citations. Previous affiliations of Berta N. Vazquez include Carlos III Health Institute & University of Barcelona.
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Journal ArticleDOI
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation
Lourdes Serrano,Paloma Martinez-Redondo,Anna Marazuela-Duque,Berta N. Vazquez,Scott J. Dooley,Philipp Voigt,David B. Beck,Noriko Kane-Goldsmith,Qiang Tong,R.M. Rabanal,Dolors Fondevila,Purificación Muñoz,Marcus Krüger,Jay A. Tischfield,Alejandro Vaquero +14 more
TL;DR: It is shown that SirT2 regulates H4K20me1 deposition through the deacetylation of H 4K16Ac and determines the levels of H4 k20me2/3 throughout the cell cycle and upon stress, the interaction betweenSirT2 and PR-Set7 increases along with the H4k20me 1 levels, suggesting a novel mitotic checkpoint mechanism.
Journal ArticleDOI
SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair.
Berta N. Vazquez,Joshua K. Thackray,Nicolas G. Simonet,Noriko Kane-Goldsmith,Paloma Martinez-Redondo,Trang Nguyen,Samuel F. Bunting,Alejandro Vaquero,Jay A. Tischfield,Lourdes Serrano +9 more
TL;DR: It is shown that SirT7‐knockout mice suffer from partial embryonic lethality and a progeroid‐like phenotype and a functional link between SIRT7‐mediated H3K18 deacetylation and the maintenance of genome integrity is established.
Journal ArticleDOI
MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3
Michele Cioffi,Mireia Vallespinos-Serrano,Sara Trabulo,Pablo J. Fernandez-Marcos,Ashley N. Firment,Berta N. Vazquez,Catarina R. Vieira,Francesca Mulero,Juan Antonio Cámara,Ultan P. Cronin,Manuel Pérez,Joaquim Soriano,Beatriz G. Gálvez,Alvaro Castells-Garcia,Verena Haage,Deepak Raj,Diego Megías,Stephan A. Hahn,Lourdes Serrano,Anne M. Moon,Alexandra Aicher,Christopher Heeschen +21 more
TL;DR: The data establish miR-93 as a negative regulator of adipogenesis and a potential therapeutic option for obesity and the metabolic syndrome and an intricate interplay between enhanced adipocyte precursor turnover and increased adipogenesis.
Journal ArticleDOI
Induction of tumor NK cell immunity by anti-CD69 antibody therapy
Enric Esplugues,Javier Vega-Ramos,David Cartoixà,Berta N. Vazquez,Ignasi Salaet,Pablo Engel,Pilar Lauzurica +6 more
TL;DR: Modulation of the innate immune system with monoclonal antibodies to host CD69 thus provides a novel means to antagonize tumor growth and metastasis.
Journal ArticleDOI
Sirtuins and DNA damage repair: SIRT7 comes to play
TL;DR: This work integrates the findings from SirT7−/− mice with the current knowledge on the mode of action of other sirtuin family members in DNA repair to emphasize their capacity to regulate chromatin structure as a response to DNA damage within the constraints imposed by cellular status.