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Beverly Mok
Researcher at Harvard University
Publications - 6
Citations - 702
Beverly Mok is an academic researcher from Harvard University. The author has contributed to research in topics: CRISPR & Genome editing. The author has an hindex of 4, co-authored 4 publications receiving 282 citations. Previous affiliations of Beverly Mok include Howard Hughes Medical Institute & Broad Institute.
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Journal ArticleDOI
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Beverly Mok,Beverly Mok,Beverly Mok,Marcos H. de Moraes,Jun Zeng,Dustin E Bosch,Anna V. Kotrys,Anna V. Kotrys,Anna V. Kotrys,Aditya Raguram,Aditya Raguram,Aditya Raguram,FoSheng Hsu,Matthew C. Radey,S. Brook Peterson,Vamsi K. Mootha,Vamsi K. Mootha,Joseph D. Mougous,David R. Liu,David R. Liu,David R. Liu +20 more
TL;DR: An interbacterial toxin that catalyses the deamination of cytidines within double-stranded DNA forms part of a CRISPR-free, RNA-free base editing system that enables manipulation of human mitochondrial DNA.
Journal ArticleDOI
Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning
Mandana Arbab,Mandana Arbab,Mandana Arbab,Max W. Shen,Beverly Mok,Beverly Mok,Beverly Mok,Christine D. Wilson,Christine D. Wilson,Christine D. Wilson,Żaneta Matuszek,Christopher A. Cassa,Christopher A. Cassa,David R. Liu,David R. Liu,David R. Liu +15 more
TL;DR: This work characterized sequence-activity relationships of cytosine and adenine base editors and used the resulting outcomes to train BE-Hive, a machine learning model that accurately predicts base editing genotypic outcomes and engineer novel CBE variants that modulate editing outcomes.
Journal ArticleDOI
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Basudeb Maji,Basudeb Maji,Basudeb Maji,Soumyashree A. Gangopadhyay,Soumyashree A. Gangopadhyay,Soumyashree A. Gangopadhyay,Miseon Lee,Miseon Lee,Mengchao Shi,Mengchao Shi,Mengchao Shi,Peng Wu,Peng Wu,Peng Wu,Robert Heler,Beverly Mok,Beverly Mok,Donghyun Lim,Donghyun Lim,Sachini U. Siriwardena,Bishwajit Paul,Bishwajit Paul,Bishwajit Paul,Vlado Dančík,Amedeo Vetere,Michael F. Mesleh,Luciano A. Marraffini,Luciano A. Marraffini,David R. Liu,David R. Liu,David R. Liu,Paul A. Clemons,Bridget K. Wagner,Amit Choudhary,Amit Choudhary,Amit Choudhary +35 more
TL;DR: A generalizable platform is reported that provided the first synthetic small-molecule inhibitors of Streptococcus pyogenes Cas9 (SpCas9) that weigh <500 Da and are cell permeable, reversible, and stable under physiological conditions.
Journal ArticleDOI
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
Luke W. Koblan,Mandana Arbab,Mandana Arbab,Mandana Arbab,Max W. Shen,Jeffrey A. Hussmann,Andrew V. Anzalone,Andrew V. Anzalone,Andrew V. Anzalone,Jordan L. Doman,Jordan L. Doman,Jordan L. Doman,Gregory A. Newby,Gregory A. Newby,Gregory A. Newby,Dian Yang,Beverly Mok,Beverly Mok,Beverly Mok,Joseph M. Replogle,Albert Xu,Tyler A Sisley,Jonathan S. Weissman,Britt Adamson,David R. Liu,David R. Liu,David R. Liu +26 more
TL;DR: In this article, a suite of engineered C•G-to-G•C base editors (CGBEs) with machine learning models were used to enable efficient, high-purity C• G-toG-C base editing.
Journal ArticleDOI
CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA
TL;DR: In this article , the authors used phage-assisted non-continuous and continuous evolution to evolve DddA variants with improved activity and expanded targeting scope, which substantially increase the effectiveness and applicability of all-protein base editing.