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Bieke Tembuyser
Researcher at Katholieke Universiteit Leuven
Publications - 4
Citations - 1480
Bieke Tembuyser is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Neovascularization & Endothelial stem cell. The author has an hindex of 3, co-authored 4 publications receiving 1109 citations.
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Journal ArticleDOI
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock,Maria Georgiadou,Sandra Schoors,Anna Kuchnio,Brian W. Wong,Anna Rita Cantelmo,Annelies Quaegebeur,Bart Ghesquière,Sandra Cauwenberghs,Guy Eelen,Li-Kun Phng,Inge Betz,Bieke Tembuyser,Katleen Brepoels,Jonathan Welti,Ilse Geudens,Inmaculada Segura,Bert Cruys,Franscesco Bifari,Ilaria Decimo,Raquel Blanco,Sabine Wyns,Jeroen Vangindertael,Susana Rocha,Russel T Collins,Sebastian Munck,Dirk Daelemans,Hiromi Imamura,Roland Devlieger,Mark H. Rider,Paul P. Van Veldhoven,Frans Schuit,Ramon Bartrons,Johan Hofkens,Peter Fraisl,Sucheta Telang,Ralph J. DeBerardinis,Luc Schoonjans,Stefan Vinckier,Jason Chesney,Holger Gerhardt,Holger Gerhardt,Mieke Dewerchin,Peter Carmeliet +43 more
TL;DR: It is shown that ECs relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the gly colytic activator PFKFB3 in ECs impaired vessel formation.
Journal ArticleDOI
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Sandra Schoors,Katrien De Bock,Anna Rita Cantelmo,Maria Georgiadou,Bart Ghesquière,Sandra Cauwenberghs,Anna Kuchnio,Brian W. Wong,Annelies Quaegebeur,Jermaine Goveia,Francesco Bifari,Xingwu Wang,Raquel Blanco,Bieke Tembuyser,Ivo Cornelissen,Ann Bouché,Stefan Vinckier,Santiago Diaz-Moralli,Holger Gerhardt,Holger Gerhardt,Sucheta Telang,Marta Cascante,Jason Chesney,Mieke Dewerchin,Peter Carmeliet +24 more
TL;DR: Although 3PO reduced glycolysis only partially and transiently in vivo, this sufficed to decrease pathological neovascularization in ocular and inflammatory models and may offer therapeutic antiangiogenic opportunities.
Journal ArticleDOI
Fibroblast growth factor signaling affects vascular outgrowth and is required for the maintenance of blood vessel integrity.
Frederik De Smet,Bieke Tembuyser,Anna Lenard,Filip Claes,Jie Zhang,Christof Michielsen,Ann Van Schepdael,Jean-Marc Herbert,Françoise Bono,Markus Affolter,Mieke Dewerchin,Peter Carmeliet +11 more
TL;DR: The use of a recently described chemical probe that selectively inhibits the action of multiple FGF receptors in combination with the zebrafish model shows the power of a small molecule probe to reveal insights into blood vessel formation and stabilization and thus of broad interest to the vascular biology community.
Journal ArticleDOI
Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish.
Annalisa Zecchin,Brian W. Wong,Bieke Tembuyser,Joris Souffreau,An Van Nuffelen,Sabine Wyns,Stefan Vinckier,Peter Carmeliet,Mieke Dewerchin +8 more
TL;DR: The findings not only show evolutionary conservation of the importance of FAO for lymphatic development, but also suggest a role for FAO in co-regulating the process of VEC-to-LEC differentiation in zebrafish in vivo.