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Xingwu Wang
Researcher at University of Science and Technology of China
Publications - 9
Citations - 1591
Xingwu Wang is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Endothelial stem cell & Angiogenesis. The author has an hindex of 9, co-authored 9 publications receiving 1279 citations. Previous affiliations of Xingwu Wang include Katholieke Universiteit Leuven.
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Journal ArticleDOI
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
Peng Jiang,Wenjing Du,Wenjing Du,Xingwu Wang,Anthony A. Mancuso,Xiang Gao,Mian Wu,Xiaolu Yang +7 more
TL;DR: It is shown that the tumour suppressor p53, the most frequently mutated gene in human tumours, inhibits the pentose phosphate pathway (PPP), which suppresses glucose consumption, NADPH production and biosynthesis.
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Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Sandra Schoors,Katrien De Bock,Anna Rita Cantelmo,Maria Georgiadou,Bart Ghesquière,Sandra Cauwenberghs,Anna Kuchnio,Brian W. Wong,Annelies Quaegebeur,Jermaine Goveia,Francesco Bifari,Xingwu Wang,Raquel Blanco,Bieke Tembuyser,Ivo Cornelissen,Ann Bouché,Stefan Vinckier,Santiago Diaz-Moralli,Holger Gerhardt,Holger Gerhardt,Sucheta Telang,Marta Cascante,Jason Chesney,Mieke Dewerchin,Peter Carmeliet +24 more
TL;DR: Although 3PO reduced glycolysis only partially and transiently in vivo, this sufficed to decrease pathological neovascularization in ocular and inflammatory models and may offer therapeutic antiangiogenic opportunities.
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The role of fatty acid β-oxidation in lymphangiogenesis
Brian W. Wong,Xingwu Wang,Annalisa Zecchin,Bernard Thienpont,Ivo Cornelissen,Joanna Kalucka,Melissa García-Caballero,Rindert Missiaen,Hongling Huang,Ulrike Bruning,Silvia Blacher,Stefan Vinckier,Jermaine Goveia,Marlen Knobloch,Hui Zhao,Cathrin Dierkes,Chenyan Shi,René Hägerling,Veronica Moral-Darde,Sabine Wyns,Martin Lippens,Sebastian Jessberger,Sarah-Maria Fendt,Aernout Luttun,Agnès Noël,Friedemann Kiefer,Bart Ghesquière,Lieve Moons,Luc Schoonjans,Mieke Dewerchin,Guy Eelen,Diether Lambrechts,Peter Carmeliet +32 more
TL;DR: In transgenic mouse models, LEC-specific loss of CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, impairs lymphatic development and replenishing acetyl coenzyme A by supplementing acetate rescues this process in vivo.
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Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism
TL;DR: This work has shown that pharmacological blockade of PFKFB3 causes a transient, partial reduction in glycolysis, and reduces pathological angiogenesis with minimal systemic harm, representing a paradigm shift in anti-angiogenic therapy from targeting angiogenic factors to focusing on vascular metabolism.
Journal ArticleDOI
c-Myc modulates microRNA processing via the transcriptional regulation of Drosha
TL;DR: It is reported that Drosha, one of the most important components of the miRNA processing machinery, is a c-Myc target gene and c- myc transactivates drosha mRNA expression, thus upregulating the Drosha protein level.