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Bihui H. Ye
Researcher at Columbia University
Publications - 26
Citations - 4759
Bihui H. Ye is an academic researcher from Columbia University. The author has contributed to research in topics: Lymphoma & Gene rearrangement. The author has an hindex of 15, co-authored 18 publications receiving 4655 citations.
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Journal ArticleDOI
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
Bihui H. Ye,Giorgio Cattoretti,Qiong Shen,Jiandong Zhang,Nicola Hawe,Rick De Waard,Cynthia C. Leung,Mahyar Nouri-Shirazi,Attilio Orazi,R. S. K. Chaganti,Paul B. Rothman,Alan M. Stall,Pier Paolo Pandolfi,Riccardo Dalla-Favera +13 more
TL;DR: BCL-6 functions as a transcriptional switch that controls germinal centre formation and may also modulate specific T-cell-mediated responses and develop an inflammatory response in multiple organs typical of a Th2-mediated hyperimmune response.
Journal ArticleDOI
Alterations of a Zinc Finger-Encoding Gene, BCL-6, in Diffuse Large-Cell Lymphoma
Bihui H. Ye,F. Lista,F. Lo Coco,Daniel M. Knowles,Kenneth Offit,R. S. K. Chaganti,Riccardo Dalla-Favera +6 more
TL;DR: A gene was cloned from chromosomal translocations affecting band 3q27 that codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors and may be a proto-oncogene specifically involved in the pathogenesis of diffuse large-cell lymphoma.
Journal ArticleDOI
BCL-6 protein is expressed in germinal-center B cells
Giorgio Cattoretti,Chih Chao Chang,Katarina Cechova,Jiandong Zhang,Bihui H. Ye,Brunangelo Falini,Diane C. Louie,Kenneth Offit,Raju S.K. Chaganti,Riccardo Dalla-Favera +9 more
TL;DR: The results indicate that the expression of the BCL-6 gene is specifically regulated during B-cell differentiation and suggest a role for B CL-6 in germinal center development or function.
Journal ArticleDOI
BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
TL;DR: It is shown here that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines and that two noncontiguous regions, including the POZ motif, mediate maximum transrepressive activity.
Journal ArticleDOI
Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma
Kenneth Offit,Francesco Lo Coco,Francesco Lo Coco,Diane C. Louie,Nasser Z. Parsa,Denis H. Y. Leung,Carol S. Portlock,Bihui H. Ye,Florigio Lista,Daniel A. Filippa,Ayala Rosenbaum,Marc Ladanyi,Suresh C. Jhanwar,Riccardo Dalla-Favera,R.S.K. Chaganti +14 more
TL;DR: Rearrangement of the bcl-6 gene correlated with a favorable clinical outcome in DLLC and may thus serve as a prognostic marker in patients with this form of malignant lymphoma.