Jiandong Zhang

TL;DR: BCL-6 functions as a transcriptional switch that controls germinal centre formation and may also modulate specific T-cell-mediated responses and develop an inflammatory response in multiple organs typical of a Th2-mediated hyperimmune response.

TL;DR: The results indicate that the expression of the BCL-6 gene is specifically regulated during B-cell differentiation and suggest a role for B CL-6 in germinal center development or function.

TL;DR: Analysis of subcellular localization, DNA binding, and transcriptional activity of two representative tumor-associated mutants in which the ankyrin domain is either terminally truncated (NFKB-2p85) or truncated and joined to an out-of-frame immunoglobulin C alpha domain (lyt-10C alpha).

TL;DR: Structurally and functionally a rearranged NFKB2 gene identified at the T cell lymphoma line, HUT78, is characterized, indicating that the rearrangement leads to the production of abnormal NF KB2 proteins capable of altering the function of the NF-kappa B transcription system.

TL;DR: The results indicate that the NFKB-2 gene codes for an inducible NF-kappa B transcription factor with the capability of differentially regulating NF- kappaB transcription depending on its abundance in the nucleus.