C
Chih Chao Chang
Researcher at Columbia University
Publications - 9
Citations - 2039
Chih Chao Chang is an academic researcher from Columbia University. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 8, co-authored 8 publications receiving 1990 citations. Previous affiliations of Chih Chao Chang include University of Milan.
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Journal ArticleDOI
BCL-6 protein is expressed in germinal-center B cells
Giorgio Cattoretti,Chih Chao Chang,Katarina Cechova,Jiandong Zhang,Bihui H. Ye,Brunangelo Falini,Diane C. Louie,Kenneth Offit,Raju S.K. Chaganti,Riccardo Dalla-Favera +9 more
TL;DR: The results indicate that the expression of the BCL-6 gene is specifically regulated during B-cell differentiation and suggest a role for B CL-6 in germinal center development or function.
Journal ArticleDOI
BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
TL;DR: It is shown here that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines and that two noncontiguous regions, including the POZ motif, mediate maximum transrepressive activity.
Journal ArticleDOI
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
Antonino Neri,Antonino Neri,Chih Chao Chang,Luigia Lombardi,Mauro Salina,Paolo Corradini,Anna Teresa Maiolo,R. S. K. Chaganti,Riccardo Dalla-Favera +8 more
TL;DR: The lyt -10 gene defines a new subfamily (rel/poly-G/ankyrin) of NF-κB-rel transcription factors with potential for oncogenic activation in human cancer.
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Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.
Bihui H. Ye,Seeta R. Chaganti,Chih Chao Chang,Huifeng Niu,Paolo Corradini,R. S. K. Chaganti,Riccardo Dalla-Favera +6 more
TL;DR: Findings indicate that t(3;14) translocations alter BCL6 expression by promoter substitution and imply that the consequence of these alterations is the deregulated expression of a normal BCL 6 protein.
Journal ArticleDOI
Transcriptional Repression of Stat6-Dependent Interleukin-4-Induced Genes by BCL-6: Specific Regulation of Iε Transcription and Immunoglobulin E Switching
Miera B. Harris,Chih Chao Chang,Michael T. Berton,Nika N. Danial,Jandong Zhang,Denise Kuehner,Bihui H. Ye,Marina Kvatyuk,Pier Paolo Pandolfi,Giorgio Cattoretti,Riccardo Dalla-Favera,Paul B. Rothman +11 more
TL;DR: BCL-6 can modulate the transcription of selective Stat6-dependent IL-4 responses, including IgE class switching in B cells, which is consistent with the role of BCL- 6 in modulating transcription from the germ line ɛ promoter.