B
Bin Fang
Researcher at University of South Florida
Publications - 98
Citations - 3232
Bin Fang is an academic researcher from University of South Florida. The author has contributed to research in topics: Cancer research & Biology. The author has an hindex of 28, co-authored 76 publications receiving 2378 citations. Previous affiliations of Bin Fang include University of Tennessee Health Science Center.
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Journal ArticleDOI
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer.
Jiannong Li,Uwe Rix,Bin Fang,Yun Bai,Arthur Edwards,Jacques Colinge,Keiryn L. Bennett,Jingchun Gao,Lanxi Song,Steven A. Eschrich,Giulio Superti-Furga,John M. Koomen,Eric B. Haura +12 more
TL;DR: The combined mass spectrometry based approach described here provides a system-level view of dasatinib action in cancer cells and suggests both functional targets and rationale combinatorial therapeutic strategies.
Journal ArticleDOI
Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
Kiran Mahajan,Domenico Coppola,Sridevi Challa,Bin Fang,Y. Ann Chen,Weiwei Zhu,Alexis S. Lopez,John M. Koomen,Robert W. Engelman,Charlene Rivera,Rebecca S. Muraoka-Cook,Jin Q. Cheng,Ernst Schönbrunn,Said M. Sebti,H. Shelton Earp,Nupam P. Mahajan +15 more
TL;DR: The RTK/Ack1/AKT pathway provides a novel target for drug discovery by uncovering that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase, Ack1 (also known as ACK or TNK2), which directly phosphorylates AKT at an evolutionarily conserved tyosine 176 in the kinase domain.
Journal ArticleDOI
Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
Xiaohong Zhao,Tint Lwin,Ariosto S. Silva,Bijal D. Shah,J Tao,Bin Fang,Liang Zhang,Kai Fu,Chengfeng Bi,Jiannong Li,Huijuan Jiang,Mark B. Meads,Timothy Jacobson,M. E. R. Silva,Allison Distler,Lancia Darville,Ling Zhang,Ying Han,Dmitri Rebatchouk,Maurizio Di Liberto,Lynn C. Moscinski,John M. Koomen,William S. Dalton,Kenneth H. Shain,Michael Wang,Eduardo M. Sotomayor,Jianguo Tao +26 more
TL;DR: This study unifies TME-mediated de novo and acquired drug resistance mechanisms and provides a novel combination therapeutic strategy against MCL and other B-cell malignancies.
Journal ArticleDOI
Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial.
Benjamin C. Creelan,Chao Wang,Jamie K. Teer,Eric M. Toloza,Jiqiang Yao,Sungjune Kim,Ana Marie Landin,John E. Mullinax,James Saller,Andreas Saltos,David Noyes,Leighann B. Montoya,Wesley Curry,Shari Pilon-Thomas,Alberto Chiappori,Tawee Tanvetyanon,Frederic J. Kaye,Zachary J. Thompson,Sean J. Yoder,Bin Fang,John M. Koomen,Amod A. Sarnaik,Dung-Tsa Chen,Jose R. Conejo-Garcia,Eric B. Haura,Scott J. Antonia +25 more
TL;DR: In this paper, a single-arm open-label phase 1 trial (NCT03215810 ) of TILs administered with nivolumab in 20 patients with advanced non-small cell lung cancer following initial progression on nivolaumab monotherapy was conducted.
Journal ArticleDOI
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
Yun Bai,Jiannong Li,Bin Fang,Arthur Edwards,Guolin Zhang,Marilyn M. Bui,Steven A. Eschrich,Soner Altiok,John M. Koomen,Eric B. Haura +9 more
TL;DR: The findings suggest that integrating global phosphoproteomics with functional analyses with kinase inhibitors can identify drivers of sarcoma growth and survival.