B
Birgit Koch
Researcher at Max Planck Society
Publications - 44
Citations - 4813
Birgit Koch is an academic researcher from Max Planck Society. The author has contributed to research in topics: Cohesin & Establishment of sister chromatid cohesion. The author has an hindex of 22, co-authored 42 publications receiving 4001 citations. Previous affiliations of Birgit Koch include European Bioinformatics Institute & Research Institute of Molecular Pathology.
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Journal ArticleDOI
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Kerstin S. Wendt,Keisuke Yoshida,Takehiko Itoh,Masashige Bando,Birgit Koch,Erika Schirghuber,Shuichi Tsutsumi,Genta Nagae,Ko Ishihara,Tsuyoshi Mishiro,Kazuhide Yahata,Fumio Imamoto,Hiroyuki Aburatani,Mitsuyoshi Nakao,Naoko Imamoto,Kazuhiro Maeshima,Katsuhiko Shirahige,Jan-Michael Peters +17 more
TL;DR: It is proposed that cohesin functions as a transcriptional insulator, and it is speculated that subtle deficiencies in this function contribute to ‘cohesinopathies’ such as Cornelia de Lange syndrome.
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Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins
Gordana Wutz,Csilla Várnai,Kota Nagasaka,David A. Cisneros,Roman R. Stocsits,Wen Tang,Stefan Schoenfelder,Gregor Jessberger,Matthias Muhar,M. Julius Hossain,Nike Walther,Birgit Koch,Moritz Kueblbeck,Jan Ellenberg,Johannes Zuber,Peter Fraser,Peter Fraser,Jan-Michael Peters +17 more
TL;DR: It is shown that cohesin suppresses compartments but is required for TADs and loops, that CTCF defines their boundaries, and that the cohes in unloading factor WAPL and its PDS5 binding partners control the length of loops.
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Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.
Silke Hauf,Elisabeth Roitinger,Birgit Koch,Christina M Dittrich,Karl Mechtler,Jan-Michael Peters +5 more
TL;DR: The analysis of these cells lines, in conjunction with biochemical experiments in vitro, indicate that Scc1 phosphorylation is dispensable for cohesin dissociation from chromosomes in early mitosis but enhances the cleavability of SCC1 by separase, and reveals that SA2 is the critical target of Plk1 in the cohesIn dissociation pathway.
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Distinct functions of condensin I and II in mitotic chromosome assembly.
TL;DR: The results reveal that condensin II and I associate with chromosomes sequentially and have distinct functions in mitotic chromosome assembly.
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Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication.
TL;DR: A cell-cycle dependence in the stability of cohesin binding to chromatin is reported, consistent with long-lived links mediating cohesion between sister chromatids.