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Anne Berscheid
Researcher at University of Tübingen
Publications - 17
Citations - 946
Anne Berscheid is an academic researcher from University of Tübingen. The author has contributed to research in topics: Staphylococcus aureus & Vancomycin. The author has an hindex of 10, co-authored 17 publications receiving 671 citations. Previous affiliations of Anne Berscheid include University of Bonn.
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Journal ArticleDOI
Human commensals producing a novel antibiotic impair pathogen colonization
Alexander Zipperer,Martin C. Konnerth,Claudia Laux,Anne Berscheid,Daniela Janek,Daniela Janek,Christopher Weidenmaier,Marc Burian,Nadine A. Schilling,Christoph Slavetinsky,Matthias Marschal,Matthias Willmann,Hubert Kalbacher,Birgit Schittek,Heike Brötz-Oesterhelt,Stephanie Grond,Andreas Peschel,Bernhard Krismer +17 more
TL;DR: It is shown that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by S. aureus, and a rare example of a non-ribosomally synthesized bioactive compound from human-associated bacteria.
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Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action.
Judith Raschig,Daniela Mailänder-Sánchez,Anne Berscheid,Jürgen Berger,Adam A. Strömstedt,L Courth,Nisar P. Malek,Heike Brötz-Oesterhelt,Jan Wehkamp +8 more
TL;DR: Surprisingly, using electron microscopy, a so far unknown net-like structure surrounding bacteria is detected, which were treated with the reduced but not the oxidized form of hBD1.
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Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability
Nadine A. Schilling,Anne Berscheid,Johannes Schumacher,Julian S. Saur,Martin C. Konnerth,Sebastian N. Wirtz,José M. Beltrán‐Beleña,Alexander Zipperer,Bernhard Krismer,Andreas Peschel,Hubert Kalbacher,Heike Brötz-Oesterhelt,Claudia Steinem,Stephanie Grond +13 more
TL;DR: L Lugdunin equalizes pH gradients in artificial membrane vesicles, thereby maintaining membrane integrity, which demonstrates that proton translocation is the mode of action (MoA).
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Kanamycin Uptake Into Escherichia coli Is Facilitated by OmpF and OmpC Porin Channels Located in the Outer Membrane
Jayesh Arun Bafna,Eulàlia Sans-Serramitjana,Silvia Acosta-Gutierrez,Igor Bodrenko,Daniel Hörömpöli,Anne Berscheid,Heike Brötz-Oesterhelt,Mathias Winterhalter,Matteo Ceccarelli +8 more
TL;DR: In this paper, it was shown that porins contribute to the translocation of the antibiotics across the bacterial outer membrane, despite decades of therapeutic application of aminoglycosides.
Journal ArticleDOI
Genome Sequence of Staphylococcus aureus VC40, a Vancomycin- and Daptomycin-Resistant Strain, To Study the Genetics of Development of Resistance to Currently Applied Last-Resort Antibiotics
Peter Sass,Anne Berscheid,Andrea Jansen,Marion Oedenkoven,Christiane Szekat,Axel Strittmatter,Gerhard Gottschalk,Gabriele Bierbaum +7 more
TL;DR: The genome of S. aureus VC40, which is resistant to the last-resort antibiotics vancomycin and daptomycin, is reported, which will allow insights into the mechanisms that convey full resistance to these compounds.