B
Brian Elenbaas
Researcher at Massachusetts Institute of Technology
Publications - 5
Citations - 2827
Brian Elenbaas is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Telomerase reverse transcriptase & Stromal cell. The author has an hindex of 5, co-authored 5 publications receiving 2724 citations. Previous affiliations of Brian Elenbaas include Biogen Idec.
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Journal ArticleDOI
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
Brian Elenbaas,Lisa Spirio,Frederick C. Koerner,Mark D. Fleming,Drazen B. Zimonjic,Joana Liu Donaher,Nicholas C. Popescu,William C. Hahn,Robert A. Weinberg +8 more
TL;DR: It is shown that introduction of three genes encoding the SV40 large-T antigen, the telomerase catalytic subunit, and an H-Ras oncoprotein into primary HMECs results in cells that form tumors when transplanted subcutaneously or into the mammary glands of immunocompromised mice.
Journal ArticleDOI
Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation
William C. Hahn,Scott K. Dessain,Scott K. Dessain,Mary W. Brooks,Jessie E. King,Brian Elenbaas,David M. Sabatini,James A. DeCaprio,Robert A. Weinberg +8 more
TL;DR: Observations define the elements of the SV40 ER required for the transformation of human cells and begin to delineate a set of intracellular pathways whose disruption, in aggregate, appears to be necessary to generate tumorigenic human cells.
Journal ArticleDOI
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation.
TL;DR: Recent advances in understanding the paracrine signaling interactions between epithelial cancer cells and associated fibroblasts are summarized and the effects of these bidirectional interactions on various aspects of carcinoma formation are examined.
Journal ArticleDOI
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
Cathrin Brisken,Anna Heineman,Tony E. Chavarria,Brian Elenbaas,Jian Tan,Sudhansu K. Dey,Jill A. McMahon,Andrew P. McMahon,Robert A. Weinberg +8 more
TL;DR: Transplantation of mammary epithelia from Wnt-4(-)/(-) mice shows that Wnt -4 has an essential role in side-branching early in pregnancy.
Journal ArticleDOI
Immortalization and transformation of primary human airway epithelial cells by gene transfer.
Ante S. Lundberg,Scott H. Randell,Sheila A. Stewart,Brian Elenbaas,Brian Elenbaas,Kimberly A. Hartwell,Mary W. Brooks,Mark D. Fleming,John C. Olsen,Scott W Miller,Robert A. Weinberg,William C. Hahn,William C. Hahn,William C. Hahn +13 more
TL;DR: These immortalized human airways epithelial cells, which have been created through the stepwise introduction of genetic alterations, provide a novel experimental model system with which to study further the biology of the airway epithelial cell and to dissect the molecular basis of lung cancer pathogenesis.